Using What We Already Have: Uncovering New Drug Repurposing Strategies in Existing Omics Data.

IF 11.2 1区医学 Q1 PHARMACOLOGY & PHARMACY

Annual review of pharmacology and toxicology Pub Date : 2020-01-08 DOI:10.1146/annurev-pharmtox-010919-023537

J. Pulley, J. Rhoads, Rebecca N. Jerome, A. Challa, K. Erreger, M. M. Joly, R. Lavieri, Kelly E. Perry, Nicole M. Zaleski, J. Shirey-Rice, D. Aronoff

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引用次数: 31

Abstract

The promise of drug repurposing is to accelerate the translation of knowledge to treatment of human disease, bypassing common challenges associated with drug development to be more time- and cost-efficient. Repurposing has an increased chance of success due to the previous validation of drug safety and allows for the incorporation of omics. Hypothesis-generating omics processes inform drug repurposing decision-making methods on drug efficacy and toxicity. This review summarizes drug repurposing strategies and methodologies in the context of the following omics fields: genomics, epigenomics, transcriptomics, proteomics, metabolomics, microbiomics, phenomics, pregomics, and personomics. While each omics field has specific strengths and limitations, incorporating omics into the drug repurposing landscape is integral to its success. Expected final online publication date for the Annual Review of Pharmacology and Toxicology Volume 60 is January 9, 2020. Please see http://www.annualreviews.org/page/journal/pubdates for revised estimates.

查看原文本刊更多论文

利用我们已有的:在现有组学数据中发现新的药物再利用策略。

药物再利用的前景是加速将知识转化为人类疾病的治疗，绕过与药物开发相关的常见挑战，以提高时间和成本效益。由于先前对药物安全性的验证，重新利用具有更高的成功机会，并允许纳入组学。假设生成组学过程为药物功效和毒性的药物再利用决策方法提供信息。本文综述了以下组学领域的药物再利用策略和方法:基因组学、表观基因组学、转录组学、蛋白质组学、代谢组学、微生物组学、表型组学、胚胎组学和人体组学。虽然每个组学领域都有特定的优势和局限性，但将组学纳入药物再利用领域是其成功不可或缺的一部分。《药理学与毒理学年鉴》第60卷的最终在线出版日期预计为2020年1月9日。修订后的估计数请参阅http://www.annualreviews.org/page/journal/pubdates。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Annual review of pharmacology and toxicology 医学-毒理学

CiteScore

27.80

自引率

0.00%

发文量

期刊介绍： Since 1961, the Annual Review of Pharmacology and Toxicology has been a comprehensive resource covering significant developments in pharmacology and toxicology. The journal encompasses various aspects, including receptors, transporters, enzymes, chemical agents, drug development science, and systems like the immune, nervous, gastrointestinal, cardiovascular, endocrine, and pulmonary systems. Special topics are also featured in this annual review.