The role of γδ T cells in the interaction between commensal and pathogenic bacteria in the intestinal mucosa.

IF 4.3 4区 医学 Q2 IMMUNOLOGY
International Reviews of Immunology Pub Date : 2023-01-01 Epub Date: 2022-05-18 DOI:10.1080/08830185.2022.2076846
Xiaoxiao Wu, Bing Gu, Huan Yang
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引用次数: 2

Abstract

The intestinal mucosa is an important structure involved in resistance to pathogen infection. It is mainly composed of four barriers, which have different but interrelated functions. Pathogenic bacteria can damage these intestinal mucosal barriers. Here, we mainly review the mechanisms of pathogen damage to biological barriers. Most γδ T cells are located on the surface of the intestinal mucosa, with the ability to migrate and engage in crosstalk with microorganisms. Commensal bacteria are involved in the activation and migration of γδ T cells to monitor the invasion of pathogens. Pathogen invasion alters the migration pattern of γδ T cells. γδ T cells accelerate pathogen clearance and limit opportunistic invasion of commensal bacteria. By discussing these interactions among γδ T cells, commensal bacteria and pathogenic bacteria, we suggest that γδ T cells may link the interactions between commensal bacteria and pathogenic bacteria.

γδ T细胞在肠粘膜共生菌和致病菌相互作用中的作用。
肠黏膜是抵抗病原体感染的重要结构。它主要由四个屏障组成,它们具有不同但相互关联的功能。病原菌会破坏这些肠黏膜屏障。在这里,我们主要综述病原体对生物屏障的破坏机制。大多数γδT细胞位于肠粘膜表面,具有迁移能力并与微生物发生串扰。共生细菌参与γδT细胞的激活和迁移,以监测病原体的入侵。病原体入侵改变了γδT细胞的迁移模式。γδT细胞加速病原体清除并限制共生细菌的机会性入侵。通过讨论γδT细胞、共生菌和致病菌之间的这些相互作用,我们认为γδT淋巴细胞可能将共生菌和致病菌之间的相互作用联系起来。
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来源期刊
CiteScore
11.00
自引率
4.00%
发文量
24
期刊介绍: This review journal provides the most current information on basic and translational research in immunology and related fields. In addition to invited reviews, the journal accepts for publication articles and editorials on relevant topics proposed by contributors. Each issue of International Reviews of Immunology contains both solicited and unsolicited review articles, editorials, and ''In-this-Issue'' highlights. The journal also hosts reviews that position the authors'' original work relative to advances in a given field, bridging the gap between annual reviews and the original research articles. This review series is relevant to all immunologists, molecular biologists, microbiologists, translational scientists, industry researchers, and physicians who work in basic and clinical immunology, inflammatory and allergic diseases, vaccines, and additional topics relevant to medical research and drug development that connect immunology to disciplines such as oncology, cardiovascular disease, and metabolic disorders. Covered in International Reviews of Immunology: Basic and developmental immunology (innate and adaptive immunity; inflammation; and tumor and microbial immunology); Clinical research (mechanisms of disease in man pertaining to infectious diseases, autoimmunity, allergy, oncology / immunology); and Translational research (relevant to biomarkers, diagnostics, vaccines, and drug development).
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