Magnetic nanoparticle-supported sulfonic acid as a green catalyst for the one-pot synthesis of 2,4,5-trisubstituted imidazoles and 1,2,4,5-tetrasubstituted imidazoles under solvent-free conditions

IF 1.3 3区化学 Q3 CHEMISTRY, ORGANIC

Heterocyclic Communications Pub Date : 2021-01-01 DOI:10.1515/hc-2020-0125

Mahnaz Sakhdari, A. Amoozadeh, E. Kolvari

引用次数: 2

Abstract

Abstract In this work, magnetic nanoparticle-supported sulfonic acid (γ-Fe2O3-SO3H) is used as an efficient catalyst in the synthesis of 2,4,5-trisubstituted imidazoles and 1,2,4,5-tetrasubstituted imidazoles in a short time (40–70 min for trisubstituted imidazoles and 30–40 min for tetrasubstituted imidazoles) and high-purity products were obtained (92–98% for trisubstituted imidazoles and 94–98% for tetrasubstituted imidazoles) in simple multicomponent reactions. The structure of these products was confirmed via FT-IR and NMR. Green and recyclable catalysts, eco-friendly and solvent-free conditions, high catalytic activity, shorter reaction time, easy recovery by an external magnet, high purity, and excellent yields are some features of these reactions. Graphical abstract

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磁性纳米粒子负载磺酸作为绿色催化剂在无溶剂条件下一锅合成2,4,5-三取代咪唑和1,2,4,5-四取代咪唑

摘要在本工作中，磁性纳米粒子负载的磺酸（γ-Fe2O3-SO3H）作为一种有效的催化剂，在短时间内合成了2,4,5-三取代咪唑和1,2,4,5-四取代咪唑（40-70 三取代咪唑和30–40的最小值在简单的多组分反应中获得了高纯度的产物（三取代咪唑为92–98%，四取代咪唑为94–98%）。通过FT-IR和NMR证实了这些产物的结构。这些反应的一些特点是绿色和可回收的催化剂、环保和无溶剂的条件、高催化活性、更短的反应时间、易于通过外部磁铁回收、高纯度和优异的产率。图形摘要

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来源期刊

Heterocyclic Communications 化学-有机化学

CiteScore

3.80

自引率

4.30%

发文量

审稿时长

1.4 months

期刊介绍： Heterocyclic Communications (HC) is a bimonthly, peer-reviewed journal publishing preliminary communications, research articles, and reviews on significant developments in all phases of heterocyclic chemistry, including general synthesis, natural products, computational analysis, considerable biological activity and inorganic ring systems. Clear presentation of experimental and computational data is strongly emphasized. Heterocyclic chemistry is a rapidly growing field. By some estimates original research papers in heterocyclic chemistry have increased to more than 60% of the current organic chemistry literature published. This explosive growth is even greater when considering heterocyclic research published in materials science, physical, biophysical, analytical, bioorganic, pharmaceutical, medicinal and natural products journals. There is a need, therefore, for a journal dedicated explicitly to heterocyclic chemistry and the properties of heterocyclic compounds.