Dexamethasone-Loaded biodegradable magnetic microparticles for treatment of CFA-induced chronic pain in rats

IF 1.8 4区化学 Q3 POLYMER SCIENCE

Designed Monomers and Polymers Pub Date : 2022-04-28 DOI:10.1080/15685551.2022.2068743

Jin Xin, Jichun Zheng, Yonghai Sun

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引用次数: 0

Abstract

ABSTRACT Traditional drug solutions or suspensions, have been shown to treat pain in complete Freund’s adjuvant (CFA)-induced chronic inflammatory pain in rats, with or without combination with magnetic therapy. In this study, we aimed to prepare, characterize, and evaluate the therapeutic effects of microparticles containing dexamethasone for local administration and treatment of chronic inflammatory pain. The results showed the following; a) Preparation and characterization: two ratios of poly(lactic-co-glycolic acid) (PLGA)/poly(lactic acid) (PLA) were used. The prepared batches were similar in size and magnetic responsiveness. The microparticle size distribution assessed via electron microscopy suggested a homogeneous distribution and absence of aggregates. Dexamethasone release profiles (microparticles synthesized with a feed ratio of 1:4) showed a sustained release in vitro and good biocompatibility with tissues. b) Therapeutic effect: the treatment effect of dexamethasone-PLGA magnetic microspheres + magnetic therapy was substantially better than that observed for other groups on day 4, as monitored by appearance, mechanical pain threshold, and histological analysis. This type of carrier could be a suitable magnetically retainable local drug delivery system for treating chronic pain.

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负载地塞米松的可生物降解磁微粒治疗慢性疼痛大鼠慢性疼痛

摘要传统药物溶液或混悬液已被证明可以治疗完全弗氏佐剂（CFA）诱导的大鼠慢性炎症性疼痛，无论是否结合磁疗。在本研究中，我们旨在制备、表征和评估含有地塞米松的微粒用于局部给药和治疗慢性炎症性疼痛的治疗效果。结果表明：；a）制备和表征：使用两种比例的聚乳酸-羟基乙酸（PLGA）/聚乳酸（PLA）。制备的批次在尺寸和磁响应性方面相似。通过电子显微镜评估的微粒大小分布表明存在均匀分布和不存在聚集体。地塞米松释放谱（以1:4的进料比合成的微粒）显示出体外持续释放和与组织的良好生物相容性。b）治疗效果：通过外观、机械疼痛阈值和组织学分析监测，地塞米松PLGA磁性微球+磁性治疗的治疗效果在第4天明显优于其他组。这种类型的载体可以是用于治疗慢性疼痛的合适的可磁性保持的局部药物递送系统。

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来源期刊

Designed Monomers and Polymers 化学-高分子科学

CiteScore

3.30

自引率

0.00%

发文量

审稿时长

2.1 months

期刊介绍： Designed Monomers and Polymers ( DMP) publishes prompt peer-reviewed papers and short topical reviews on all areas of macromolecular design and applications. Emphasis is placed on the preparations of new monomers, including characterization and applications. Experiments should be presented in sufficient detail (including specific observations, precautionary notes, use of new materials, techniques, and their possible problems) that they could be reproduced by any researcher wishing to repeat the work. The journal also includes macromolecular design of polymeric materials (such as polymeric biomaterials, biomedical polymers, etc.) with medical applications. DMP provides an interface between organic and polymer chemistries and aims to bridge the gap between monomer synthesis and the design of new polymers. Submssions are invited in the areas including, but not limited to: -macromolecular science, initiators, macroinitiators for macromolecular design -kinetics, mechanism and modelling aspects of polymerization -new methods of synthesis of known monomers -new monomers (must show evidence for polymerization, e.g. polycondensation, sequential combination, oxidative coupling, radiation, plasma polymerization) -functional prepolymers of various architectures such as hyperbranched polymers, telechelic polymers, macromonomers, or dendrimers -new polymeric materials with biomedical applications