Cardio metabolic traits and lung function: A Mendelian Randomization study

IF 2.7 4区医学 Q2 GENETICS & HEREDITY

Genes and Environment Pub Date : 2018-09-15 DOI:10.1183/13993003.CONGRESS-2018.PA1277

M. Wielscher, C. Minelli, A. Amaral, Juha Auwinen, S. Sebert, D. Jarvis, M. Järvelin

引用次数: 0

Abstract

Background: Observational studies show that lung function is associated with cardio metabolic traits (e.g. BMI, coronary artery disease, type 2 diabetes, blood pressure) and markers of systemic inflammation (e.g. CRP). However, these associations may be confounded by shared risk factors (e.g. smoking). In this study we investigated whether the associations of lung function with cardio metabolic traits may be causal. Methods: We selected instrumental variables from published large scale genome-wide association studies, including SNPs with P Results: MR estimates suggest a negative association of BMI with FEV1 and FVC and a positive association with FEV1/FVC (P Conclusion: We show, by using genetic instruments, that the observational associations of BMI, T2D, SBP, CRP and lung function are unlikely to be confounded and may be causal. Investigation of possible pleiotropic effects are currently being performed to further explore these findings. Funding: EU H2020 grant 633212

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心脏代谢特征和肺功能:一项孟德尔随机研究

背景:观察性研究表明，肺功能与心脏代谢特征(如BMI、冠状动脉疾病、2型糖尿病、血压)和全身炎症标志物(如CRP)有关。然而，这些关联可能被共同的危险因素(如吸烟)所混淆。在这项研究中，我们调查了肺功能与心脏代谢特征之间是否存在因果关系。方法:我们从已发表的大规模全基因组关联研究中选择了工具变量，包括带有P的snp。结果:MR估计表明BMI与FEV1和FVC呈负相关，与FEV1/FVC呈正相关(P)。结论:我们表明，通过使用遗传仪器，BMI、T2D、SBP、CRP和肺功能的观察性关联不太可能混淆，可能是因果关系。目前正在对可能的多效性效应进行调查，以进一步探索这些发现。资助:EU H2020资助633212

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Genes and Environment Biochemistry, Genetics and Molecular Biology-Genetics

CiteScore

4.00

自引率

0.00%

发文量

审稿时长

27 weeks

期刊介绍： Genes and Environment is an open access, peer-reviewed journal that aims to accelerate communications among global scientists working in the field of genes and environment. The journal publishes articles across a broad range of topics including environmental mutagenesis and carcinogenesis, environmental genomics and epigenetics, molecular epidemiology, genetic toxicology and regulatory sciences. Topics published in the journal include, but are not limited to, mutagenesis and anti-mutagenesis in bacteria; genotoxicity in mammalian somatic cells; genotoxicity in germ cells; replication and repair; DNA damage; metabolic activation and inactivation; water and air pollution; ROS, NO and photoactivation; pharmaceuticals and anticancer agents; radiation; endocrine disrupters; indirect mutagenesis; threshold; new techniques for environmental mutagenesis studies; DNA methylation (enzymatic); structure activity relationship; chemoprevention of cancer; regulatory science. Genetic toxicology including risk evaluation for human health, validation studies on testing methods and subjects of guidelines for regulation of chemicals are also within its scope.