Clinical significance of CD10 expression in cancer

Abstract

CD10 is a zinc-dependant metalloproteinase, the expression of which can be observed on numerous tissues such as epithelial cells of the lung, intestine, kidney, breast and placenta. Earlier research studies have shown, that CD10 expression is commonly observed in different types of carcinomas. Furthermore, there is an association between CD10 expression and tumor size and histological grade. Expression of CD10 might help with assessment of disease status, progression and prognosis.