Holistic chemical characterization of Zaoren Anshen preparations based on HPLC fingerprint and multi-components quantification

IF 1 4区化学 Q4 BIOCHEMICAL RESEARCH METHODS

Journal of Liquid Chromatography & Related Technologies Pub Date : 2023-03-16 DOI:10.1080/10826076.2023.2206667

Man-Jiang Xie, Jie Wang, Chenguang Dong, P. Tu, Qingying Zhang

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引用次数: 0

Abstract

Abstract Based on HPLC fingerprint analysis and multi-components quantification, a simple, sensible, and reliable HPLC-UV method, capable of qualitatively and quantitatively characterizing the main chemical markers of all medicinal herbs of Zaoren Anshen (ZRAS) prescription by one injection, was firstly developed. Then, three different dosage forms of ZRAS preparations, i.e., capsule, granule, and oral liquid, were analyzed and compared systematically, indicating the similarity and difference in chemical markers of the three ZRAS preparations. The strategy of combining HPLC chemical fingerprint and multi-components quantification in one injection was rather practical, powerful and useful in characterizing the main chemical markers of ZRAS preparations, which was a benefit for holistic quality evaluation and control of ZRAS preparations. Moreover, the present results provide sound scientific data for further studies on the effective constituents and quality control of ZRAS preparations. GRAPHICAL ABSTRACT

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基于高效液相色谱指纹图谱和多组分定量的皂仁安神制剂整体化学表征

摘要在高效液相色谱指纹图谱分析和多组分定量的基础上，首次建立了一种简便、灵敏、可靠的HPLC-UV方法，能够一次注射定性、定量地表征枣仁安神方所有药材的主要化学标志物。然后，对三种不同剂型的ZRAS制剂，即胶囊、颗粒剂和口服液进行了系统的分析和比较，表明三种ZRAS制剂在化学标志物上的相似性和差异性。将高效液相色谱化学指纹图谱和多组分定量相结合的策略在表征ZRAS制剂的主要化学标志物方面相当实用、有力和有用，有利于对ZRAS制剂进行全面质量评价和控制。此外，本研究结果为进一步研究ZRAS制剂的有效成分和质量控制提供了可靠的科学依据。图形摘要

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来源期刊

Journal of Liquid Chromatography & Related Technologies 化学-分析化学

CiteScore

2.80

自引率

0.00%

发文量

审稿时长

4.9 months

期刊介绍： The Journal of Liquid Chromatography & Related Technologies is an internationally acclaimed forum for fast publication of critical, peer reviewed manuscripts dealing with analytical, preparative and process scale liquid chromatography and all of its related technologies, including TLC, capillary electrophoresis, capillary electrochromatography, supercritical fluid chromatography and extraction, field-flow technologies, affinity, and much more. New separation methodologies are added when they are developed. Papers dealing with research and development results, as well as critical reviews of important technologies, are published in the Journal.