Ameliorative potential of Anacyclus pyrethrum extract in generalized seizures in rat: Possible cholinergic mediated mechanism

IF 0.9 4区医学 Q4 PHARMACOLOGY & PHARMACY

Bangladesh Journal of Pharmacology Pub Date : 2019-12-14 DOI:10.3329/bjp.v14i4.40537

Kenza Bezza, Zineb El Gabbas, Jawad Laadraoui, M. Laaradia, Sara Oufquir, A. Chait

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引用次数: 5

Abstract

The present study evaluates the anticonvulsant activity of the roots of Anacyclus pyrethrum using pilocarpine-induced experimental model of epilepsy in rat, and to determine its possible anticonvulsant mechanism. Ethanol extract (200 and 400 mg/kg) or alkylamides (25 and 50 mg/kg) was administered orally 45 min before the injection of pilocarpine-induced (400 mg/kg) seizures. The possible anticonvulsant mechanism was investigated by testing the effect of atropine (2 mL/kg) and scopolamine (1 mg/kg). The scoring of seizure severity, seizures time latency, duration of total seizures and percentage of mortality protection were recorded. Ethanol extract and alkylamides prolonged the time of onset seizure and decreased the duration of seizures compared to control group (p<0.001). The seizure protection was 100%. The co-administered of ethanol extract of A. pyrethrum and alkylamides with atropine completely abolished the pilocarpine-induced seizures. Video Clip of Methodology: Anticonvulsant effect: 6 min 7 sec: Full Screen Alternate

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拟除虫菊提取物对大鼠全身性癫痫发作的改善潜力:可能的胆碱能介导机制

本研究采用匹罗卡品致痫大鼠实验模型，评价除虫菊根的抗惊厥活性，并探讨其可能的抗惊厥机制。在注射匹罗卡品诱导癫痫发作(400 mg/kg)前45分钟口服乙醇提取物(200和400 mg/kg)或烷基酰胺(25和50 mg/kg)。通过观察阿托品(2ml /kg)和东莨菪碱(1mg /kg)的作用，探讨其可能的抗惊厥作用机制。记录癫痫发作严重程度评分、癫痫发作潜伏期评分、总发作持续时间评分和死亡率保护率评分。与对照组相比，乙醇提取物和烷基酰胺可延长癫痫发作时间，缩短癫痫发作持续时间(p<0.001)。扣押保护是100%。拟除虫菊乙醇提取物和烷基酰胺与阿托品联合使用可完全消除匹罗卡品诱发的癫痫发作。方法视频剪辑:抗惊厥效果:6分7秒:全屏交替

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来源期刊

Bangladesh Journal of Pharmacology PHARMACOLOGY & PHARMACY-

CiteScore

1.50

自引率

18.80%

发文量

审稿时长

>12 weeks

期刊介绍： Bangladesh Journal of Pharmacology (Bangladesh J Pharmacol) is an open access, video component, peer-reviewed journal of the Bangladesh Pharmacological Society (BDPS). A scholarly publication is defined ''open access'' when there are no financial, legal or technical barriers to accessing it. Anyone can read, download, copy, distribute, print or use it in educational purpose within the legal agreements. Peer review of a manuscript means the evaluation of research work by one or more people with similar competences. It can be open or blind. We do the single-blind peer review. Our readers want to know the methodology used by the researchers which is very important to get the results. The video clip of one of the methodologies is prepared by the authors and submit it to publish.