Synthesis of Thiolated Cashew Gum and Its Evaluation as an Improved Mucoadhesive Agent in Drug Delivery

Q4 Pharmacology, Toxicology and Pharmaceutics

International Journal of Drug Delivery Technology Pub Date : 2023-03-25 DOI:10.25258/ijddt.13.1.10

P. Bandyopadhyay, A. Nayak

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引用次数: 0

Abstract

The objectives of present research work were to extract cashew exudate gum (CG), perform thiolation of extracted CG, and evaluate the synthesized thiolated cashew exudate gum (TCG) as a mucoadhesive agent in designing metronidazole mucoadhesive gels and metronidazole mucoadhesive buccal discs. The CG was thiolated or thiol-modifi ed via esterifi cation utilizing thioglycolic acid and hydrochloric acid. Metronidazole mucoadhesive gels and metronidazole mucoadhesive buccal discs made of unmodifi ed CG and TCG (as mucoadhesive agent) were formulated and evaluated to reveal their bio-mucoadhesive potentials in drug delivery. The yield of thiolated product (TCG) was 56.24%, and the thiol-group content in TCG was found to be 9.06 mM of thiol group/g of CG. FTIR analysis indicated the thiolation of CG in the synthesized TCG. Both types of formulations (mucoadhesive gels and buccal discs) made of TCG exhibited excellent improved ex-vivo bio-mucoadhesion and consistent pattern of metronidazole releasing over a prolonged time. The synthesized TCG can be utilized as an improved mucoadhesive material in designing bio-mucoadhesive systems for drug delivery.

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硫基腰果胶的合成及其作为一种改进的粘膜粘合剂的评价

本研究的目的是提取腰果渗出胶（CG），对提取的CG进行巯基化处理，并评价合成的巯基化腰果渗出液胶（TCG）作为甲硝唑粘黏凝胶和甲硝唑粘黏颊片的粘黏剂。利用巯基乙酸和盐酸通过酯化阳离子对CG进行巯基化或硫醇改性。配制并评价了未改性CG和TCG（作为粘附剂）制成的甲硝唑粘附胶凝胶和甲硝唑粘附颊片，以揭示其在药物递送中的生物粘附势。巯基化产物（TCG）的产率为56.24%，并且发现TCG中的巯基含量为9.06mM巯基/g CG。FTIR分析表明，合成的TCG中CG发生了巯基化反应。由TCG制成的两种类型的制剂（粘膜粘附凝胶和颊盘）都表现出极好的体外生物粘膜粘附性改善和甲硝唑在长时间内的一致释放模式。合成的TCG可作为一种改进的粘膜粘附材料用于设计用于药物递送的生物粘膜粘附系统。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

International Journal of Drug Delivery Technology Pharmacology, Toxicology and Pharmaceutics-Pharmaceutical Science

CiteScore

0.70

自引率

0.00%

发文量

期刊介绍： International Journal of Drug Delivery Technology (IJDDT) provides the forum for reporting innovations, production methods, technologies, initiatives and the application of scientific knowledge to the aspects of pharmaceutics, including controlled drug release systems, drug targeting etc. in the form of expert forums, reviews, full research papers, and short communications.