Nephroprotective efficacy of Asparagus racemosus root extract on acetaminophen-induced renal injury in rats

Q3 Agricultural and Biological Sciences

Acta Biologica Szegediensis Pub Date : 2018-08-23 DOI:10.14232/abs.2018.1.17-23

Suchismita Roy, Shrabani Pradhan, S. Mandal, Koushika Das, D. Nandi

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Abstract

Acetaminophen-induced renal necrosis and insufficiency occurs in patients with acetaminophen overdose. Renal failure is rapidly assuming epidemic proportions globally. In absence of reliable and effective nephroprotective drugs, strategies towards exploring alternative therapies for treatment of kidney diseases are essential. Asparagus racemosus is a medicinal plant used for treatment of various ailments. This research was undertaken to investigate the protective effect of ethanol fraction of A. racemosus roots extract in acetaminophen-induced uraemia and renal failure in rats. Rats were co-administered with acetaminophen injection and oral administration of A. racemosus roots extract in an attempt of protection against renal failure. Uremic biomarkers significantly decreased, and elevated levels of antioxidant enzymes were found, in the animals treated with ethanol fraction of A. racemosus when compared with acetaminophen treated uremic animals. Also, histology of kidneys showed control like structure in animals treated with this extract but severe damage in the uremic animals. HPLC analysis of the ethanol fraction of A. racemosus roots extract revealed eight compounds out of which one had a retention time near to the quercetin standard. It may be concluded that this extract of A. racemosus has therapeutically useful nephroprotective potential.

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芦笋根提取物对对对乙酰氨基酚肾损伤的保护作用

对乙酰氨基酚过量的患者会出现对乙酰氨基苯酚引起的肾坏死和肾功能不全。肾衰竭在全球范围内迅速蔓延。在缺乏可靠有效的肾脏保护药物的情况下，探索肾脏疾病替代疗法的策略至关重要。总状芦笋是一种药用植物，用于治疗各种疾病。本研究旨在研究外消旋A.raceosus根提取物乙醇部分对对乙酰氨基酚诱导的大鼠尿毒症和肾功能衰竭的保护作用。大鼠同时注射对乙酰氨基酚和口服外消旋A.raceosus根提取物，试图预防肾衰竭。与对乙酰氨基酚治疗的尿毒症动物相比，用消旋A.racemosus乙醇部分治疗的动物的尿毒症生物标志物显著降低，抗氧化酶水平升高。此外，在用该提取物治疗的动物中，肾脏的组织学显示出类似对照的结构，但在尿毒症动物中表现出严重损伤。对A.raceosus根提取物的乙醇部分的HPLC分析揭示了八种化合物，其中一种的保留时间接近槲皮素标准。可以得出结论，这种外消旋A.racemosus提取物具有治疗有用的肾保护潜力。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Acta Biologica Szegediensis Agricultural and Biological Sciences-Agricultural and Biological Sciences (all)

CiteScore

1.00

自引率

0.00%

发文量

期刊介绍： Acta Biologica Szegediensis (ISSN 1588-385X print form; ISSN 1588-4082 online form), a member of the Acta Universitatis Szegediensis family of scientific journals (ISSN 0563-0592), is published yearly by the University of Szeged. Acta Biologica Szegediensis covers the growth areas of modern biology and publishes original research articles and reviews, involving, but not restricted to, the fields of anatomy, embryology and histology, anthropology, biochemistry, biophysics, biotechnology, botany and plant physiology, all areas of clinical sciences, conservation biology, ecology, genetics, microbiology, molecular biology, neurosciences, paleontology, pharmacology, physiology and pathophysiology, and zoology.