Cell – extracellular matrix interaction in glioma growth. I n silico model

IF 1.5 Q3 MATHEMATICAL & COMPUTATIONAL BIOLOGY
V. Kalinin
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引用次数: 6

Abstract

Abstract The study aims to investigate the role of viscoelastic interactions between cells and extracellular matrix (ECM) in avascular tumor growth. Computer simulations of glioma multicellular tumor spheroid (MTS) growth are being carried out for various conditions. The calculations are based on a continuous model, which simulates oxygen transport into MTS; transitions between three cell phenotypes, cell transport, conditioned by hydrostatic forces in cell–ECM composite system, cell motility and cell adhesion. Visco-elastic cell aggregation and elastic ECM scaffold represent two compressible constituents of the composite. Cell–ECM interactions form a Transition Layer on the spheroid surface, where mechanical characteristics of tumor undergo rapid transition. This layer facilitates tumor progression to a great extent. The study demonstrates strong effects of ECM stiffness, mechanical deformations of the matrix and cell–cell adhesion on tumor progression. The simulations show in particular that at certain, rather high degrees of matrix stiffness a formation of distant multicellular clusters takes place, while at further increase of ECM stiffness subtumors do not form. The model also illustrates to what extent mere mechanical properties of cell–ECM system may contribute into variations of glioma invasion scenarios.
胶质瘤生长中的细胞-细胞外基质相互作用。I n硅模型
摘要本研究旨在探讨细胞与细胞外基质(ECM)之间的粘弹性相互作用在无血管肿瘤生长中的作用。计算机模拟胶质瘤多细胞肿瘤球体(MTS)的生长正在各种条件下进行。这些计算是基于一个连续模型,该模型模拟氧气向MTS的输送;三种细胞表型之间的转换,细胞运输,由细胞- ecm复合系统中的流体静力调节,细胞运动和细胞粘附。粘弹性细胞聚集体和弹性ECM支架是复合材料的两种可压缩成分。细胞- ecm相互作用在球体表面形成过渡层,肿瘤的力学特性在此发生快速转变。这一层在很大程度上促进了肿瘤的进展。该研究表明,ECM刚度、基质的机械变形和细胞-细胞粘附对肿瘤进展有很强的影响。模拟特别表明,在一定的、相当高的基质刚度下,会形成远端多细胞簇,而在进一步增加ECM刚度时,则不会形成亚肿瘤。该模型还说明了细胞- ecm系统的机械特性在多大程度上可能影响胶质瘤侵袭情景的变化。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Journal of Integrative Bioinformatics
Journal of Integrative Bioinformatics Medicine-Medicine (all)
CiteScore
3.10
自引率
5.30%
发文量
27
审稿时长
12 weeks
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