Immunologically effective biomaterials-enhanced vaccines against infection of pathogenic microorganisms

IF 3.5 Q1 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH
Qi Wei , Shixian Liu , Xu Huang , Hua Xin , Jianxun Ding
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引用次数: 3

Abstract

Infectious diseases are severe public health events that threaten global health. Prophylactic vaccines have been considered as the most effective strategy to train the immune system to recognize and clear pathogenic infections. However, the existing vaccines against infectious diseases have several limitations, such as difficulties in mass manufacturing and storage, weak immunogenicity, and low efficiency of available adjuvants. Biomaterials, especially functional polymers, are expected to break through these bottlenecks based on the advantages of biocompatibility, degradability, controlled synthesis, easy modification, precise targeting, and immune modulation, which are excellent carriers and adjuvants of vaccines. This review mainly summarizes the application of immunologically effective polymers-enhanced vaccines against viruses- and bacteria-related infectious diseases and predicted their potential improvements.

抗病原微生物感染的免疫有效生物材料增强疫苗
传染病是威胁全球健康的严重公共卫生事件。预防性疫苗被认为是训练免疫系统识别和清除致病性感染的最有效策略。然而,现有的传染病疫苗存在大量生产和储存困难、免疫原性弱、可用佐剂效率低等局限性。生物材料,特别是功能聚合物,具有生物相容性、可降解性、合成可控、易修饰、精准靶向、免疫调节等优点,是疫苗的优良载体和佐剂,有望突破这些瓶颈。本文主要综述了免疫有效的聚合物增强疫苗在病毒和细菌相关传染病中的应用,并对其未来的发展前景进行了展望。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Biosafety and Health
Biosafety and Health Medicine-Infectious Diseases
CiteScore
7.60
自引率
0.00%
发文量
116
审稿时长
66 days
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