Brucellosis and inflammatory markers: data from south-east province of Turkey

Journal of Clinical and Analytical Medicine Pub Date : 2018-11-01 DOI:10.4328/jcam.5906

Selçuk Nazik

{"title":"Brucellosis and inflammatory markers: data from south-east province of Turkey","authors":"Selçuk Nazik","doi":"10.4328/jcam.5906","DOIUrl":null,"url":null,"abstract":"DOI: 10.4328/JCAM.5906 Received: 27.05.2018 Accepted: 06.06.2018 Published Online: 10.06.2018 Printed: 01.11.2018 J Clin Anal Med 2018;9(6): 578-81 Corresponding Author: Selçuk Nazik, Department of Infectious Disease and Clinical Microbiology, Kahramanmaraş Sütçü İmam University, Kahramanmaraş, 46100, Turkey. GSM: +905055019161 F.: +90 3443003434 E-Mail: dr.selcuknazik@hotmail.com ORCID ID: 0000-0003-0587-0104 Abstract Aim: Brucellosis is the most common zoonosis in the world. It is commonly seen in developing countries and causes economic loss. Brucellosis is a major public health problem. Therefore, early diagnosis of brucellosis is very important. The current study aims to investigate WBC, CRP, ESR, NLR, PLR and MPV levels, when brucellosis was first diagnosed. Material and Method: The study included a total of 394 patients who were enrolled at our hospital between the dates of January 2007 and June 2017. Among these patients 197 were cases of brucellosis and 197 were healthy controls. Results: WBC values were statistically significantly lower in the patients with brucellosis, compared to the control group (p < 0.001). Otherwise, NLR, CRP, ESR and MPV values were statistically significantly higher in the patients with brucellosis, compared to the control group (<0.001, 0.005, 0.001, 0.042, p values respectively). PLR values did not differ statistically significantly between the groups (p = 0.468). Discussion: NLR is obtained from a whole blood count. NLR increases in inflammatory conditions and this increase are regarded as a marker of systemic inflammation. In a study, it was determined that NLR values were significantly higher in the brucellosis group than the control group (p = 0.032). Mean platelet volume indicates platelet size and activity. It is also used as a marker of platelet dysfunction. Increased MPV level is associated with thrombotic disorders and endothelial dysfunction. In the study by Aktar et al. MPV values were significantly higher in the brucellosis group than in the control group (p=0.026). Conclusion: NLR and MPV have been shown to be important markers that can be used in the first diagnosis of brucellosis.","PeriodicalId":44485,"journal":{"name":"Journal of Clinical and Analytical Medicine","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2018-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Clinical and Analytical Medicine","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.4328/jcam.5906","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}

引用次数: 0

Abstract

DOI: 10.4328/JCAM.5906 Received: 27.05.2018 Accepted: 06.06.2018 Published Online: 10.06.2018 Printed: 01.11.2018 J Clin Anal Med 2018;9(6): 578-81 Corresponding Author: Selçuk Nazik, Department of Infectious Disease and Clinical Microbiology, Kahramanmaraş Sütçü İmam University, Kahramanmaraş, 46100, Turkey. GSM: +905055019161 F.: +90 3443003434 E-Mail: dr.selcuknazik@hotmail.com ORCID ID: 0000-0003-0587-0104 Abstract Aim: Brucellosis is the most common zoonosis in the world. It is commonly seen in developing countries and causes economic loss. Brucellosis is a major public health problem. Therefore, early diagnosis of brucellosis is very important. The current study aims to investigate WBC, CRP, ESR, NLR, PLR and MPV levels, when brucellosis was first diagnosed. Material and Method: The study included a total of 394 patients who were enrolled at our hospital between the dates of January 2007 and June 2017. Among these patients 197 were cases of brucellosis and 197 were healthy controls. Results: WBC values were statistically significantly lower in the patients with brucellosis, compared to the control group (p < 0.001). Otherwise, NLR, CRP, ESR and MPV values were statistically significantly higher in the patients with brucellosis, compared to the control group (<0.001, 0.005, 0.001, 0.042, p values respectively). PLR values did not differ statistically significantly between the groups (p = 0.468). Discussion: NLR is obtained from a whole blood count. NLR increases in inflammatory conditions and this increase are regarded as a marker of systemic inflammation. In a study, it was determined that NLR values were significantly higher in the brucellosis group than the control group (p = 0.032). Mean platelet volume indicates platelet size and activity. It is also used as a marker of platelet dysfunction. Increased MPV level is associated with thrombotic disorders and endothelial dysfunction. In the study by Aktar et al. MPV values were significantly higher in the brucellosis group than in the control group (p=0.026). Conclusion: NLR and MPV have been shown to be important markers that can be used in the first diagnosis of brucellosis.

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布鲁氏菌病和炎症标记物:来自土耳其东南部省的数据

DOI:10.4328/JCAM.5906接收日期：2018年5月27日接受日期：2018月6日在线发布日期：2018年年6印刷日期：2018年度11月1日《临床分析医学杂志》；9（6）：578-81通讯作者：Selçuk Nazik，KahramanmaraşSütçüïmam大学传染病和临床微生物学系，土耳其Kahramanmarş，46100。GSM：+905055019161传真：+90 3443003434电子邮件：dr.selcuknazik@hotmail.comORCID ID:0000-0003-0587-0104摘要目的：布鲁氏菌病是世界上最常见的人畜共患病。它在发展中国家很常见，会造成经济损失。布鲁氏菌病是一个主要的公共卫生问题。因此，布鲁氏菌病的早期诊断是非常重要的。本研究旨在调查首次诊断布鲁氏菌病时的WBC、CRP、ESR、NLR、PLR和MPV水平。材料和方法：该研究包括2007年1月至2017年6月期间在我院登记的394名患者。在这些患者中，197例为布鲁氏菌病，197例是健康对照。结果：与对照组相比，布鲁氏菌病患者的WBC值显著降低（p＜0.001）。此外，布鲁氏杆菌病患者的NLR、CRP、ESR和MPV值也显著高于对照组（分别＜0.001、0.005、0.001、0.042，p值）。PLR值在两组之间没有统计学上的显著差异（p=0.468）。讨论：NLR是从全血计数中获得的。炎症条件下NLR增加，这种增加被视为全身炎症的标志。在一项研究中，布鲁氏菌病组的NLR值明显高于对照组（p=0.032）。平均血小板体积表示血小板大小和活性。它也被用作血小板功能障碍的标志物。MPV水平升高与血栓性疾病和内皮功能障碍有关。在Aktar等人的研究中，布鲁氏菌病组的MPV值显著高于对照组（p=0.026）。

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Journal of Clinical and Analytical Medicine MEDICINE, GENERAL & INTERNAL-

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期刊介绍： The Annals of Clinical and Analytical Medicine is an international open-access journal containing peer-reviewed high-quality articles on clinical medicine in the areas of all research study types, reviews, and case reports. Our journal has become an important platform with the help of language support services, which make it easier for writers who have English as their second language to share their clinical experiences with the world.