Gene-environment interplay in early life cognitive development

IF 3.3 2区 心理学 Q1 PSYCHOLOGY, MULTIDISCIPLINARY
Sophie von Stumm , Radhika Kandaswamy , Jessye Maxwell
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引用次数: 0

Abstract

Children's differences in early life cognitive development are driven by the interplay of genetic and environmental factors, but identifying replicable gene-environment interactions (GxE) has proven difficult. We systematically tested GxE effects in the prediction of cognitive development from 2 to 4 years, using polygenic scores (PGS) for years spent in education and 39 measures of the home and neighborhood environment. Data came from up to 6973 unrelated individuals from the Twins Early Development Study (TEDS), a UK population-representative cohort. The environmental measures accounted together for 20.6% of the variance in cognitive development, while the PGS accounted for 0.5% (p < .001). We observed substantial gene-environment correlations but found no conclusive evidence for GxE effects. While associations between PGS and cognitive development were weak, genetic and environmental factors had direct and additive (i.e., main effects) rather than interactive influences on early life cognitive development.

早期认知发展中的基因-环境相互作用
儿童早期认知发展的差异是由遗传和环境因素的相互作用驱动的,但确定可复制的基因-环境相互作用(GxE)已被证明是困难的。我们系统地测试了GxE在预测2 - 4岁认知发展中的作用,使用了教育年限的多基因分数(PGS)和家庭和社区环境的39种测量方法。数据来自双胞胎早期发展研究(TEDS)中多达6973名不相关的个体,这是一个英国人口代表性队列。环境措施合计占认知发展差异的20.6%,而PGS只占0.5% (p <措施)。我们观察到大量的基因与环境相关,但没有发现GxE效应的确凿证据。虽然PGS与认知发展之间的关联较弱,但遗传和环境因素对早期生活认知发展的影响是直接和附加的(即主要影响),而不是相互作用的。
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来源期刊
Intelligence
Intelligence PSYCHOLOGY, MULTIDISCIPLINARY-
CiteScore
5.80
自引率
13.30%
发文量
64
审稿时长
69 days
期刊介绍: This unique journal in psychology is devoted to publishing original research and theoretical studies and review papers that substantially contribute to the understanding of intelligence. It provides a new source of significant papers in psychometrics, tests and measurement, and all other empirical and theoretical studies in intelligence and mental retardation.
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