The interactions between extracellular vesicles and mesenchymal stem cells: Their potential roles in osteoarthritis development and cartilage repair

Qiong Yang , Danyang Yue , Qian Ren , Guoqing Xia , Baihui Zhang , Yinyin Qin , Tianfei Ran , Min Wang , Li Pei , Jun Pan
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引用次数: 2

Abstract

Osteoarthritis (OA) is a chronic cartilage degeneration disease affecting total joint and with a wide global impact. Stem cell therapy has emerged as a potential stock for the treatment of OA. Exosomes are the mainstay of the paracrine function in stem cells, acting as an important mediator of intercellular communication. The purpose of this review is to sort out the close relationships among OA, MSCs, and exosomes. We find though majority of researches on exosomes focus on normal MSC-derived exosomes to restore tissues, studies demonstrate that OA or inflammation-induced microenvironment can alter exosomes, which in turn affect the biological behaviors and functions of receptor cells in the joint cavity, including proliferation and differentiation of MSCs. Exosomes, MSCs and OA form a triangular relationship. More future research directions are exploring the effects of OA-derived exosomes on chondrogenic differentiation of MSCs, especially on mitochondria to disclose the reasons for failure endogenous repair by MSCs, and normalizing the OA exosomes to treat OA.

Abstract Image

细胞外小泡和间充质干细胞之间的相互作用:它们在骨关节炎发展和软骨修复中的潜在作用
骨关节炎(OA)是一种影响全关节的慢性软骨退行性疾病,具有广泛的全球性影响。干细胞疗法已成为OA治疗的潜在储备。外泌体是干细胞旁分泌功能的支柱,是细胞间通讯的重要媒介。本文旨在梳理OA、MSCs和外泌体之间的密切关系。我们发现,尽管大多数关于外泌体的研究都集中在正常的msc来源的外泌体来恢复组织,但研究表明OA或炎症诱导的微环境可以改变外泌体,从而影响关节腔内受体细胞的生物学行为和功能,包括MSCs的增殖和分化。外泌体、间充质干细胞和OA形成三角关系。未来更多的研究方向是探索OA来源的外泌体对MSCs成软骨分化的影响,特别是对线粒体的影响,以揭示MSCs内源性修复失败的原因,并使OA外泌体正常化以治疗OA。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Extracellular vesicle
Extracellular vesicle Biochemistry, Genetics and Molecular Biology (General)
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