Treatment of tibial traumatic osteomyelitis with negative pressure closure drainage combined with open bone grafting or bone migration and its effect on the levels of CRP, TNF-α and IL-6 in the serum

IF 0.8 4区医学 Q3 MEDICINE, GENERAL & INTERNAL

African Health Sciences Pub Date : 2023-10-11 DOI:10.24205/03276716.2020.1075

Xinqiang Wang, Liangbang Wu, Yuehong Zhang, Zhen-hai Hou, Longbao Zheng, Zenghui Gu

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引用次数: 0

Abstract

Objective: To observe the effect of negative pressure closure drainage combined with open bone grafting or bone migration inthe treatment of tibial traumatic osteomyelitis. Methods: Eighty-six (86) cases of tibial traumatic osteomyelitis admitted to Hospital of the Chinese people's Liberation Armyfrom September 2017 to September 2018 were randomly divided into control group and observation group, forty-three (43)cases each. Debridement, open bone grafting or bone migration was given to the control group.The observation group was treated with negative pressure closed drainage on the basis of the control group. In addition, the serumcomponents such as CRP, TNF-α, IL-6 of the control group and observation group were detected respectively after surgery. Results: Observation group granulation cover wound, fracture healing time was shorter than the control group, fracture healingrate was better than the control group, the difference has statistical significance (P<0.05). By comparing serum CRP, TNF-α,IL-6 levels before and after treatment in the two groups, it was found that the observation group was lower than the controlgroup (P<0.05, respectively). Serum CRP, TNF-α, IL-6 levels were significantly (P<0.05). Conclusion: The treatment of tibial traumatic osteomyelitis with negative pressure closure drainage combined with open bonegrafting or bone displacement has a good effect on fracture healing and is worth popularizing. Keywords: Bone removal; CRP; IL-6; Negative pressure closure drainage; Tibia; TNF-α; Traumatic osteomyelitis.

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负压闭合引流联合开放性骨移植或骨迁移治疗胫骨外伤性骨髓炎及其对血清CRP、TNF-α和IL-6水平的影响

目的:观察负压封闭引流联合开放植骨或骨迁移治疗胫骨外伤性骨髓炎的效果。方法:选取2017年9月~ 2018年9月中国人民解放军医院收治的86例胫骨外伤性骨髓炎患者，随机分为对照组和观察组，各43例。对照组行清创、开放植骨或骨迁移。观察组在对照组的基础上给予负压封闭引流治疗。对照组和观察组术后分别检测CRP、TNF-α、IL-6等血清成分。结果:观察组肉芽覆盖创面后，骨折愈合时间短于对照组，骨折愈合效果好于对照组，差异有统计学意义(P<0.05)。比较两组患者治疗前后血清CRP、TNF-α、IL-6水平，观察组低于对照组(P均<0.05)。血清CRP、TNF-α、IL-6水平显著高于对照组(P<0.05)。结论:负压封闭引流联合开放植骨或骨移位治疗胫骨外伤性骨髓炎骨折愈合效果好，值得推广。关键词:去骨;c反应蛋白;il - 6;负压封闭排水;胫骨;肿瘤坏死因子-α;创伤性骨髓炎。

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来源期刊

African Health Sciences MEDICINE, GENERAL & INTERNAL-

CiteScore

2.30

自引率

0.00%

发文量

179

审稿时长

>12 weeks

期刊介绍： The African Health Sciences is an internationally refereed journal publishing original articles on research, clinical practice, public health, policy, planning, implementation and evaluation, in the health and related sciences relevant to Africa and the tropics. Its objectives are to: Advocate for and promote the growth of reading culture in sub Saharan Africa; Provide a high quality journal in which health and policy and other researchers and practitioners in the region can and world wide, can publish their work; Promote relevant health system research and publication in the region including alternative means of health care financing, the burden of and solution of health problems in marginalized urban and rural communities amongst the displaced and others affected by conflict; Promote research and the systematic collection and collation and publication of data on diseases and conditions of equity and influence; Promote development of evidence-based policies and guidelines for clinical, public health and other practitioners. African Health Sciences acknowledges support provided by the African Health Journals Partnership Project that is funded by the US National Institutes of Health (through the National Library of Medicine and the Fogarty International Center) and facilitated by the Council of Science Editors.