Phytonanomedicine: A therapeutic approach for cervical cancer

Abstract

Cervical cancer has historically been the deadliest malignancy in women. It continues to create several health issues, particularly in developing countries. Current management techniques include cisplatin-based chemoradiotherapy and surgical procedures. These treatments have some drawbacks, such as low absorption, side effects, systemic toxicity, the development of resistance to various therapeutics, and targeting that is too broad and insufficiently precise. To compensate for these shortcomings, researchers are still hunting for novel anticancer drugs. Plant-derived phytochemicals and their derivatives have promise for improving cancer treatment efficacy while reducing adverse effects. Phytomolecules are utilized to treat cancer, but they are difficult to work with since they have low bioavailability, excessive dosages, negative side effects and low therapeutic indices. They must be administered in high doses to be effective and nanotechnology can be utilized to overcome these obstructions. Piperlongumine, rutin, quercetin, lycopene, leutin, curcumin, green tea polyphenols, and other phytomolecules have been loaded into a carrier called nanophytomedicine to be beneficial in chemoprevention and chemotherapy. Nanocarriers have a high level of biocompatibility, biodegradability, and biological stability. Nano-based drug delivery systems are an excellent approach to improving therapeutic specificity, making it easier for the body to absorb it reducing the drug's breakdown and systemic toxicity. This review looks at phytonanomedicine and how it can be used to treat cervical cancer instead of traditional chemo-radiotherapy.