Efficacy of moxibustion by stimulating acupoints of Danzhong (CV 17) and Ganshu (BL 18) on hyperplasia of mammary gland in rats

IF 2 4区医学 Q2 INTEGRATIVE & COMPLEMENTARY MEDICINE

Journal of Traditional Chinese Medicine Pub Date : 2018-02-01 DOI:10.1016/j.jtcm.2018.01.007

Yang Jiamin , Wu Jihui , Shen Xiaoyu , Zhang Mei , Liu Zhenzhen , Qi Dandan , Zhou Jin , Cui Xiao , Zhang Lufen , Li Yuhang

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引用次数: 4

Abstract

OBJECTIVE

To evaluate the efficacy of moxibustion, through stimulating acupoints of Danzhong (CV 17) and Ganshu (BL 18) in rats with hyperplasia of mammary gland (HMG) which induced by estrogen and progestogen.

METHODS

Thirty female Sprague-Dawley rats were randomly divided into saline control group, HMG model group, and HMG moxibustion group with 10 in each group. Saline control was the group injected by saline. HMG model were created by injection of estrogen and progestogen. Moxibustion group was also injected of estrogen and progestogen with moxibustion at the same time. The Changes of nipple diameter and height were measured. The rats’ skin temperature was recorded by an infrared thermal camera at the nipples, mammary areas, Danzhong (CV 17) and Ganshu (BL 18). Pathological changes of mammary gland in rats were also observed under light microscope.

RESULTS

The diameter and height of the nipples in model group were prominently bigger and higher than that in control group (P < 0.01). The diameter and height in moxibustion group were prominently smaller and lower than that in model group (P < 0.01), and there was no significant difference between moxibustion group and control group. Compared with control group, skin temperature of the nipples, mammary area, and acupoints Danzhong (CV 17) and Ganshu (BL 18) decreased prominently in model group (P < 0.01-0.05). Compared with model group, skin temperature of that in moxibustion group increased prominently (P < 0.05).

CONCLUSION

Treatment with moxibustion can effectively decrease the HMG rats’ nipple diameter and height, and increase the skin temperature in HMG model rats at the nipples, mammary areas, Danzhong (CV 17) and Ganshu (BL 18). This study convinces the therapeutic effect of moxibustion on mammary gland hyperplasia.

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灸丹中穴(CV 17)和肝俞穴(BL 18)对大鼠乳腺增生的影响

目的通过刺激丹中穴(CV 17)和肝俞穴(BL 18)，观察艾灸对雌激素、孕激素诱导的乳腺增生(HMG)大鼠的疗效。方法30只雌性sd大鼠随机分为生理盐水对照组、HMG模型组和HMG艾灸组，每组10只。生理盐水对照组为生理盐水注射组。通过注射雌激素和孕激素建立HMG模型。艾灸组患者在艾灸的同时注射雌激素和孕激素。测量乳头直径和高度的变化。用红外热像仪记录大鼠乳头、乳房、丹中(CV 17)和肝俞(BL 18)的皮肤温度。光镜下观察大鼠乳腺的病理变化。结果模型组大鼠乳头直径和高度明显大于对照组(P <0.01)。艾灸组大鼠的直径和高度明显小于模型组(P <0.01)，艾灸组与对照组比较差异无统计学意义。与对照组比较，模型组大鼠乳头、乳腺部位、丹中穴(CV 17)、肝俞穴(BL 18)皮肤温度显著降低(P <0.01 - -0.05)。与模型组比较，艾灸组大鼠皮肤温度显著升高(P <0.05)。结论艾灸治疗可有效降低HMG模型大鼠乳头直径和乳头高度，提高HMG模型大鼠乳头、乳腺区域、丹中(CV 17)和肝枢(BL 18)的皮肤温度。本研究证实了艾灸对乳腺增生的治疗作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Traditional Chinese Medicine INTEGRATIVE & COMPLEMENTARY MEDICINE-

CiteScore

2.40

自引率

3.80%

发文量

32269

审稿时长

2 months

期刊介绍： Journal of Traditional Chinese Medicine（JTCM） is devoted to clinical and theortical research on the use of acupuncture and Oriental medicine. The main columns include Clinical Observations, Basic Investigations, Reviews, Questions and Answers, an Expert''s Forum, and Discussions of Clinical Cases. Its key topics include acupuncture and electro-acupuncture, herbal medicine, homeopathy, masseotherapy, mind-body therapies, palliative care, and other CAM therapies.