The medicinal chemistry of Urtica dioica L.: from preliminary evidence to clinical studies supporting its neuroprotective activity

IF 4.8 3区 化学 Q1 CHEMISTRY, MEDICINAL
Prabhakar Semwal, Abdur Rauf, Ahmed Olatunde, Pooja Singh, Mohamed Y. Zaky, Md. Mozahidul Islam, Anees Ahmed Khalil, Abdullah S. M. Aljohani, Waleed Al Abdulmonem, Giovanni Ribaudo
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Abstract

Urtica dioica is a perennial herb from the family of Urticaceae that is commonly known as stinging nettle. This plant is widespread in Europe, Africa, America, and a part of Asia, as it adapts to different environments and climatic conditions. The leaves, stalk, and bark of U. dioica found applications in the field of nutrition, cosmetics, textile, pest control and pharmacology. In this connection, bioactive chemical constituents such as flavonoids, phenolic acids, amino acids, carotenoids, and fatty acids have been isolated from the plant. With this review, we aim at providing an updated and comprehensive overview of the contributions in literature reporting computational, in vitro, pre-clinical and clinical data supporting the therapeutic applications of U. dioica. Experimental evidence shows that U. dioica constituents and extracts can provide neuroprotective effects by acting through a combination of different molecular mechanisms, that are discussed in the review. These findings could lay the basis for the identification and design of more effective tools against neurodegenerative diseases.

Graphical Abstract

Abstract Image

荨麻疹的药物化学:从初步证据到支持其神经保护作用的临床研究
荨麻是荨麻科的多年生草本植物,通常被称为荨麻。这种植物广泛分布于欧洲、非洲、美洲和亚洲的部分地区,因为它能适应不同的环境和气候条件。薯蓣的叶、茎、皮在营养、化妆品、纺织、害虫防治和药理等方面都有广泛的应用。在这方面,生物活性化学成分,如黄酮类化合物、酚酸、氨基酸、类胡萝卜素和脂肪酸已经从植物中分离出来。在这篇综述中,我们的目标是提供一个最新的和全面的文献报告的贡献,计算,体外,临床前和临床数据支持杜鹃花的治疗应用。实验证据表明,薯蓣成分及其提取物可能通过多种分子机制的结合发挥神经保护作用,本文将对此进行讨论。这些发现可以为识别和设计更有效的治疗神经退行性疾病的工具奠定基础。图形抽象
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来源期刊
Natural Products and Bioprospecting
Natural Products and Bioprospecting CHEMISTRY, MEDICINAL-
CiteScore
8.30
自引率
2.10%
发文量
39
审稿时长
13 weeks
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