Correction of Cytokine Profile in Autoimmune Diseases with Cryopreserved Embryofetoplacental Complex Products

Q4 Medicine

Problems of Cryobiology and Cryomedicine Pub Date : 2022-06-30 DOI:10.15407/cryo32.02.121

A. Goltsev, O. Lutsenko, Kateryna Yampolska, Yuliia Gaevska, M. Bondarovych, Lyudmyla Ostankova, L. Sokil, L. Stepaniuk, Ihor Grisha

引用次数: 0

Abstract

In this work, we experimentally substantiated the possibility of correcting the cytokine profile to reduce the inflammation in mice with adjuvant arthritis (AA) via combined use of lyophilized human cord blood leukoconcentrate (lHCBL) and cryopreserved human placental extract (cHPE). Adjuvant arthritis was modelled in CBA/H mice. To day 7 after pathology induction, the animals were injected with lHCBL and cHPE singly or in combination. To days 14 and 28 of observation, all the introduced products showed a therapeutic effect. To 28 day of observation, the efficiency of combined use of lHCBL and cHPE was 3.1 and 2.5 times higher vs. the monotherapy (respectively), likely resulting from their synergy in respect to a decrease in arthritis index, TNFα concentration, impact of lHCBL and cHPE on IFNγ and IL-6 levels, correspondingly.

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用冷冻胚胎胎盘复合物制品校正自身免疫性疾病的细胞因子谱

在这项工作中，我们通过实验证实了通过联合使用冻干的人脐血白细胞浓缩物（lHCBL）和冷冻保存的人胎盘提取物（cHPE）来纠正细胞因子谱以减少佐剂性关节炎（AA）小鼠炎症的可能性。在CBA/H小鼠中建立佐剂性关节炎模型。至病理诱导后第7天，对动物单独或联合注射lHCBL和cHPE。到观察的第14天和第28天，所有引入的产品都显示出治疗效果。观察28天后，联合使用lHCBL和cHPE的效率分别是单一治疗的3.1倍和2.5倍，这可能是由于它们在关节炎指数、TNFα浓度、lHCBL与cHPE对IFNγ和IL-6水平的影响方面的协同作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Problems of Cryobiology and Cryomedicine Medicine-Medicine (miscellaneous)

CiteScore

0.60

自引率

0.00%

发文量

期刊介绍： The Journal publishes the reviews and original papers on cryobiological and cryomedical research, in particular the elucidation of mechanisms of injuries occurring in biological objects and caused by the influence of low and ultra low temperatures; natural resistance of biologicals to cold and their recovery post effect; the development of effective methods of cryoprotection and technology of storage of biological resources under hypothermic and ultra low temperatures, application of hypothermia, cryotherapy and cryopreserved biologicals for treating various pathologies; cell and tissue based therapies and other issues of low-temperature biology and medicine, as well as development of devices and equipment for low temperature biology and medicine. The journal covers all topics related to low temperature biology, medicine and engineering. These include but are not limited to: low temperature storage of biologicals (human, animal or plant cells, tissues, and organs), including preparation for storage, thawing/warming, cell and tissue culturing etc. response of biologicals to low temperature; cold adaptation of animals and plants; utilisation of low temperature in medicine; experimental and clinical transplantation, cell and tissue based therapies; developing of cryobiological and cryomedical devices; organisation and functioning of low temperature banks etc.