Ketogenic diet in ATAD3A mutation carriers may not improve cerebellar atrophy but some clinical features [Letter]

Abstract

Krankenanstalt Rudolfstiftung, Messerli Institute, Vienna, Austria Dear editor With interest I read the article by Madhoun et al about a 4.5-year-old female with multisystem mitochondrial disorder (MID) due to the variant c.251T>C in the ATAD3A gene. The patient was reported to have profited from the ketogenic diet (KD) by slowing the progression of cerebellar atrophy, and improving vitality, interaction, moaning, carrying, tremor, and weakness. I have the following comments and concerns. It is quite unlikely that the cerebellar volume increased upon application of the KD. More likely is that the increase in the relative sagittal length of the cerebellum was due to variability of repeated measurements or simply due to the growing cerebellum in this developing child. Potential volumetric changes can be only confirmed by investigating a series of patients but not by assessing a single case. The tremor in the patient was attributed to Parkinsonism most likely upon the phenotype as a hand pill rolling tremor. We should be informed about the DatScan results, if the tremor responded to L-DOPA, and if there were any other stigmata of Parkinsonism in this patient. More likely than Parkinson's tremor is a cerebellar tremor in the light of progressive cerebellar atrophy. A hand pill rolling tremor may also occur with a cerebellar syndrome. MRI in figure 1 suggests that there was also atrophy of the spinal cord. It is conceivable that muscle weakness in the described patient was attributable to involvement of the anterior horn cells. Were there any indications for neuronopathy in the presented patient? Though optic atrophy may be a feature of ATAD3A mutations, it was not reported as a feature of the index case. Optic atrophy may be subtle and not visible on ophthalmologic or imaging investigations but only on functional tests. Thus, we should be informed if latency and amplitude of visually evoked potentials were prolonged respectively reduced. We should be informed if muscle weakness was attributed to affection of the central nervous system or due to myopathy. It should be mentioned if deep tendon reflexes were reduced or exaggerated. A normal needle EMG does not exclude myopathy. Since seizures have been reported as a phenotypic feature of ATAD3A mutations, we should be informed about the history in this regards and the EEG findings. Correspondence: Josef Finsterer Krankenanstalt Rudolfstiftung, Messerli Institute, Postfach 20, 1180 Vienna, Austria Tel +43 1 711 657 2085 Fax +43 17 1165 Email fifigs1@yahoo.de The Application of Clinical Genetics Dovepress open access to scientific and medical research