Bioactive Chitosan-Based Organometallic Scaffolds for Tissue Engineering and Regeneration

IF 7.1 2区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Topics in Current Chemistry Pub Date : 2022-02-12 DOI:10.1007/s41061-022-00364-y

Solmaz Zakhireh, Jaleh Barar, Khosro Adibkia, Younes Beygi-Khosrowshahi, Marziyeh Fathi, Hossein Omidain, Yadollah Omidi

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引用次数: 6

Abstract

Captivating achievements in developing advanced hybrid biostructures through integrating natural biopolymers with inorganic materials (e.g., metals and metalloids) have paved the way towards the application of bioactive organometallic scaffolds (OMSs) in tissue engineering and regenerative medicine (TERM). Of various biopolymers, chitosan (CS) has been used widely for the development of bioactive OMSs, in large part due to its unique characteristics (e.g., biocompatibility, biodegradability, surface chemistry, and functionalization potential). In integration with inorganic elements, CS has been used to engineer advanced biomimetic matrices to accommodate both embedded cells and drug molecules and serve as scaffolds in TERM. The use of the CS-based OMSs is envisioned to provide a new pragmatic potential in TERM and even in precision medicine. In this review, we aim to elaborate on recent achievements in a variety of CS/metal, CS/metalloid hybrid scaffolds, and discuss their applications in TERM. We also provide comprehensive insights into the formulation, surface modification, characterization, biocompatibility, and cytotoxicity of different types of CS-based OMSs.

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生物活性壳聚糖基有机金属支架用于组织工程和再生

通过将天然生物聚合物与无机材料(如金属和类金属)相结合，在开发先进的杂交生物结构方面取得了令人瞩目的成就，这为生物活性有机金属支架(OMSs)在组织工程和再生医学(TERM)中的应用铺平了道路。在各种生物聚合物中，壳聚糖(CS)由于其独特的特性(如生物相容性、生物可降解性、表面化学和功能化潜力)被广泛用于开发生物活性的oms。在与无机元素的整合中，CS已被用于设计先进的仿生基质，以容纳嵌入的细胞和药物分子，并作为TERM的支架。基于cs的oms的使用有望在TERM甚至精准医学中提供新的实用潜力。本文综述了近年来CS/metal、CS/metalloid复合支架的研究进展，并对其在TERM中的应用进行了讨论。我们还提供了对不同类型的基于cs的oms的配方，表面改性，表征，生物相容性和细胞毒性的全面见解。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Topics in Current Chemistry Chemistry-General Chemistry

CiteScore

13.70

自引率

1.20%

发文量

期刊介绍： Topics in Current Chemistry is a journal that presents critical reviews of present and future trends in modern chemical research. It covers all areas of chemical science, including interactions with related disciplines like biology, medicine, physics, and materials science. The articles in this journal are organized into thematic collections, offering a comprehensive perspective on emerging research to non-specialist readers in academia or industry. Each review article focuses on one aspect of the topic and provides a critical survey, placing it in the context of the collection. Selected examples highlight significant developments from the past 5 to 10 years. Instead of providing an exhaustive summary or extensive data, the articles concentrate on methodological thinking. This approach allows non-specialist readers to understand the information fully and presents the potential prospects for future developments.