Presepsin: a biomarker of early-onset neonatal sepsis

Q4 Medicine

Italian journal of anatomy and embryology Pub Date : 2022-12-27 DOI:10.36253/ijae-13787

Valentina Botondi, E. D’Adamo, O. Trubiani, D. Gazzolo

引用次数: 0

Abstract

Neonatal early-onset sepsis represents one of the most common diseases leading to morbidity and mortality in preterm infants. A prompt diagnosis is still a challenge in the clinical practice due to several biases affecting the current standard of care performance. In this regard, the soluble cluster of differentiation CD14 subtype, namely Presepsin, has been shown to be a promising diagnostic biomarker of sepsis in newborns. Although Presepsin provides high accuracy and short results output, its reliability in daily clinical practice is still an issue that needs further investigation. Therefore, in the present review we offer an overview of Presepsin role as diagnostic tool of early-neonatal onset sepsis.

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Presepsin:早发新生儿败血症的生物标志物

新生儿早发脓毒症是导致早产儿发病和死亡的最常见疾病之一。在临床实践中，由于影响当前护理表现标准的一些偏见，及时诊断仍然是一个挑战。在这方面，CD14亚型的可溶性分化簇，即Presepsin，已被证明是新生儿败血症的一个有希望的诊断生物标志物。Presepsin虽然准确度高，结果输出时间短，但其在日常临床实践中的可靠性仍有待进一步研究。因此，在目前的审查，我们提供的Presepsin的作用作为诊断工具的新生儿早发脓毒症的概述。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Italian journal of anatomy and embryology Medicine-Embryology

CiteScore

0.20

自引率

0.00%

发文量

期刊介绍： The Italian Journal of Anatomy and Embryology, founded in 1901 by Giulio Chiarugi, Anatomist at Florence University, is a peer-reviewed journal sponsored by the Italian Society of Anatomy and Embryology. The journal publishes original papers, invited review articles, historical article, commentaries, obituitary, and book reviews. Its main focus is to understand anatomy through an analysis of structure, function, development and evolution. Priority will be given to studies of that clearly articulate their relevance to the anatomical community. Focal areas include: experimental studies, contributions based on molecular and cell biology and on the application of modern imaging techniques; comparative functional morphology; developmental biology; functional human anatomy; methodological innovations in anatomical research; significant advances in anatomical education. Studies that are essentially descriptive anatomy are appropriate only if they communicate clearly a broader functional or evolutionary significance. All papers should be submitted in English and must be original works that are unpublished and not under consideration by another journal. An international Editorial Board and reviewers from the anatomical disciplines guarantee a rapid review of your paper within two to three weeks after submission.