Chemical, Biological, and Pharmacological Prospects of Caffeic Acid

Q3 Biochemistry, Genetics and Molecular Biology

Biointerface Research in Applied Chemistry Pub Date : 2022-09-11 DOI:10.33263/briac134.324

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引用次数: 2

Abstract

There are many proven beneficial pharmacological effects of polyphenols, and these compounds have been tremendously studied for their role in the human body. Daily intake of polyphenols has shown beneficial effects on the immune system. Polyphenols are the natural compounds present in plants as secondary metabolites. Caffeic acid (CA) is the major one among other compounds of hydroxycinnamic acid, which plays an important role as an antioxidant, anticancer, antidiabetic, antihypertensive, antimicrobial, hepatoprotective, antiviral, etc. It is found in most herbal plants. CA produces its pharmacological effect by altering the activity of various key enzymes. It reduces the blood glucose level by inhibiting enzymes α-amylase and α-glucosidase in type-2 diabetes. It shows anticancer and anti-inflammatory activity by inhibiting various transcript factors. The small part of the esterified form of CA is absorbed in the stomach, and the rest of the part is the breakdown in its free form by the microbial esterases in the colon. It enters intestinal cells via active transport mediated by MCT. The maximum plasma concentration is seen after one hour of food ingestion. Methylation, sulphation, and glucuronidation take place after absorption and are excreted primarily through urine. The purpose of this review is to enhance researchers' knowledge to conduct more studies to reveal and optimize CA's biological and pharmacological properties. Based on its pharmacological activity, this compound can be used as a natural safeguard to replace synthetic antibiotics and other synthetic medicine to reduce the medicinal cost and side effects.

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咖啡酸的化学、生物学和药理学前景

多酚有许多已证实的有益药理作用，这些化合物在人体中的作用已被大量研究。每天摄入多酚对免疫系统有好处。多酚是植物次生代谢产物中的天然化合物。咖啡酸(cafic acid, CA)是羟基肉桂酸的主要化合物之一，具有抗氧化、抗癌、降糖、降压、抗菌、保肝、抗病毒等重要作用。它存在于大多数草本植物中。CA通过改变各种关键酶的活性来产生其药理作用。它通过抑制2型糖尿病患者α-淀粉酶和α-葡萄糖苷酶来降低血糖水平。它通过抑制多种转录因子显示抗癌和抗炎活性。羧酸酯化后的一小部分在胃中被吸收，其余部分则被结肠中的微生物酯酶分解为游离形式。它通过MCT介导的主动转运进入肠细胞。血药浓度最大值出现在进食一小时后。甲基化、磺化和葡萄糖醛酸化在吸收后发生，主要通过尿液排出。本文综述的目的是提高研究者的认识，以便开展更多的研究，揭示和优化CA的生物学和药理特性。基于其药理活性，该化合物可作为替代合成抗生素和其他合成药物的天然保障剂，降低药物成本和副作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Biointerface Research in Applied Chemistry CHEMISTRY, APPLIED-

CiteScore

4.80

自引率

0.00%

发文量

256

期刊介绍： Biointerface Research in Applied Chemistry is an international and interdisciplinary research journal that focuses on all aspects of nanoscience, bioscience and applied chemistry. Submissions are solicited in all topical areas, ranging from basic aspects of the science materials to practical applications of such materials. With 6 issues per year, the first one published on the 15th of February of 2011, Biointerface Research in Applied Chemistry is an open-access journal, making all research results freely available online. The aim is to publish original papers, short communications as well as review papers highlighting interdisciplinary research, the potential applications of the molecules and materials in the bio-field. Our aim is to encourage scientists to publish their experimental and theoretical results in as much detail as possible.