Research progress in the application of mesenchymal stem cells in the treatment of knee osteoarthritis

国际生物医学工程杂志 Pub Date : 2019-08-28 DOI:10.3760/CMA.J.ISSN.1673-4181.2019.04.014

Shuwei Gong, Aifeng Liu, Mubin Wei, J. He

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Abstract

Knee osteoarthritis (KOA) is the main cause of knee pain and disability in the elderly. KOA is a complex disease that is controlled by a variety of pathogenic factors, including general physical factors such as age, gender, obesity, family history, and mechanical factors, and unfavorable mechanical factors to the knee joint, such as trauma, sports injuries, and daily routines. The prevalence of KOA is related to genetic factors. Currently, conservative treatment has limited effects to this disease, and knee joint replacement is usually associated with many complications. Mesenchymal stem cells(MSCs) were first discovered in the bone marrow and subsequently found in peripheral blood, cord blood, skeletal muscle, heart and adipose tissue, which have high plasticity and pluripotency. The discovery of MSCs provides a new method for the treatment of KOA. Due to its powerful cartilage repair and regeneration function, researchers have conducted a large number of experimental studies on the efficacy, safety and mechanism of MSCs in the treatment of KOA in recent years. In this paper, the above studies presented were systematically reviewed. Key words: Mesenchymal stem cells; Knee osteoarthritis; Application

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间充质干细胞在膝骨关节炎治疗中的应用研究进展

膝关节骨性关节炎（KOA）是导致老年人膝关节疼痛和残疾的主要原因。KOA是一种由多种致病因素控制的复杂疾病，包括年龄、性别、肥胖、家族史和机械因素等一般身体因素，以及创伤、运动损伤和日常生活等对膝关节不利的机械因素。KOA的患病率与遗传因素有关。目前，保守治疗对这种疾病的效果有限，膝关节置换术通常会带来许多并发症。间充质干细胞最初在骨髓中发现，随后在外周血、脐带血、骨骼肌、心脏和脂肪组织中发现，它们具有高可塑性和多能性。MSCs的发现为治疗KOA提供了一种新的方法。由于其强大的软骨修复和再生功能，近年来，研究人员对MSCs治疗KOA的疗效、安全性和机制进行了大量的实验研究。本文对上述研究进行了系统的综述。关键词：间充质干细胞；膝骨关节炎；应用程序

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国际生物医学工程杂志

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1974