‘Distribution of Hepatitis C Virus genotypes in northern Greece in the last decade: descriptive analysis and clinical correlations’

IF 1.1 Q4 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH
G. Gioula, E. Sinakos, E. Gigi, I. Goulis, T. Vasiliadis, F. Minti, E. Akriviadis
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引用次数: 0

Abstract

Hepatitis C virus (HCV) represents a major public health problem, while the identification of a HCV genotype is clinically very important for therapy prescription. The aim of the present study was to determine the HCV genotype distribution patients from northern Greece with HCV RNA positive viral load and to identify whether there is a shift in this distribution, during 2009–2017. The study was performed on 915 HCV positive patients and according to the results, genotype 3 was the most prevalent genotype (Ν = 395, 43.2%) followed by genotype 1 (Ν = 361, 39.5%). Regarding the gender of the patients, genotype 1 was mostly detected in women. Moreover, genotype 1 was associated with higher viral loads, while genotype 3 was most frequently detected in patients with a history of intravenous drug use. In conclusion, our results show that genotype 3 is the most prevalent genotype in Greece during the last decade as opposed to older epidemiological studies, likely due to intravenous drug use becoming the major source of infection.
“过去十年中希腊北部丙型肝炎病毒基因型的分布:描述性分析和临床相关性”
丙型肝炎病毒(HCV)是一个主要的公共卫生问题,而HCV基因型的鉴定在临床上对治疗处方非常重要。本研究的目的是确定希腊北部HCV RNA阳性病毒载量患者的HCV基因型分布,并确定2009-2017年期间这种分布是否发生了变化。本研究对915例HCV阳性患者进行了研究,结果表明,基因型3是最常见的基因型(=395,43.2%),其次是基因型1(=361,39.5%)。就患者的性别而言,基因型1主要在女性中检测到。此外,基因型1与较高的病毒载量有关,而基因型3在有静脉注射吸毒史的患者中最常见。总之,我们的研究结果表明,在过去十年中,基因型3是希腊最流行的基因型,而不是以前的流行病学研究,这可能是因为静脉注射药物成为主要的感染源。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Global Health Epidemiology and Genomics
Global Health Epidemiology and Genomics PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH-
CiteScore
1.40
自引率
0.00%
发文量
10
审稿时长
20 weeks
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