Integration of Histopathology and Clinical Microbiology in the Diagnosis of Infectious Diseases: Focus on Mycoses

Abstract

Identification and interpretation of microorganisms on histopathology is a skill set critical for both anatomic pathologists and clinical microbiologists. Microorganisms, and fungi in particular, develop structural properties differently within tissue than on an agar plate. For proper diagnoses the interpreter must be familiar with both phenotypes. Here, we review the specifics of fungal growth in tissue, including organism morphology, host reaction, and limitations for accurate histology identification.