Biodegradable Zn–Sr alloys with enhanced mechanical and biocompatibility for biomedical applications

Q1 Engineering

Smart Materials in Medicine Pub Date : 2022-01-01 DOI:10.1016/j.smaim.2021.12.004

Yingchao Su , Jiayin Fu , Shaokang Du , Elias Georgas , Yi-Xian Qin , Yufeng Zheng , Yadong Wang , Donghui Zhu

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引用次数: 8

Abstract

Zinc (Zn) is a new generation of biodegradable metal as temporary biomedical implants with a promising degradation rate. However, its clinical applications have been limited because of the insufficient mechanical properties. Considering the degradation property and biocompatibility, we proposed Zn–Sr alloys after extrusion treatments to simultaneously improve the mechanical strength and ductility. The in vitro and in vivo degradation and biocompatibility were also evaluated using electrochemical and immersion corrosion tests, various cell and bacterial models, together with subcutaneous and femoral implantations in rats. Results showed that the extruded Zn-0.7Sr alloys exhibited two times higher mechanical strengths (∼120 MPa) and better ductility (∼10%) than the pure Zn counterparts. The Zn–Sr alloys provided enhanced in vitro and in vivo biocompatibility along with promising antibacterial properties.

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可生物降解的Zn–Sr合金，具有增强的机械性能和生物相容性，用于生物医学应用

锌(Zn)是新一代生物可降解金属，是一种具有良好降解性能的生物医用临时植入物。然而，由于其力学性能不足，其临床应用受到限制。考虑到锌锶合金的降解性能和生物相容性，我们提出了经过挤压处理的锌锶合金，以同时提高机械强度和塑性。通过电化学和浸没腐蚀试验、各种细胞和细菌模型以及大鼠皮下和股骨植入，评估了其体外和体内降解和生物相容性。结果表明，挤压Zn-0.7 sr合金的力学强度(~ 120mpa)和延展性(~ 10%)均比纯Zn合金高2倍。锌锶合金具有较好的体内外生物相容性和良好的抗菌性能。

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