Canine Sertoli cell tumor: anti-Müllerian hormone, inhibin B, and estrone sulphate

Clinical theriogenology Pub Date : 2023-04-17 DOI:10.58292/ct.v15.9437

Fiona Herzog, Daniel W. Adams, Alissa St. Blanc, J. Lee, C. Pinto, I. Langohr

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Abstract

A unilaterally castrated male boxer was referred for chronic generalized alopecia and pruritus. Physical examination revealed symmetrical alopecia, pendulous prepuce, lichenification of the scrotum, and enlargement of mammary papillae. Penile/preputial cytology revealed superficial epithelial cells. Transabdominal ultrasonographic examination revealed a globoid mass with heterogenous echogenicity in the left caudal abdomen. The presumptive diagnosis was Sertoli cell tumor (SCT) associated with cryptorchidism. Exploratory laparotomy and histology of the removed mass confirmed the diagnosis. Three weeks after surgery, serum anti-Müllerian hormone (AMH) concentrations decreased from 8,435 to 56 ng/ml and inhibin B decreased from 805 to < 6 pg/ml. Two months after surgery dermatoses subsided and there was substantial regression of enlarged nipples. This report highlights the diagnostic value of practical procedures (penile/preputial cytology, transabdominal ultrasonography, and measurement of serum AMH and inhibin B concentrations) to aid in the diagnosis of cryptorchidism and SCT, especially in patients with generalized skin conditions.

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犬支持细胞瘤:抗勒氏激素，抑制素B和硫酸雌酮

一名单侧阉割的男性拳击手因慢性全身性脱发和瘙痒症被转诊。体格检查显示对称性脱发、包皮下垂、阴囊地衣化和乳腺乳头增大。阴茎/包皮细胞学检查显示浅表上皮细胞。经腹部超声检查发现左尾腹部有一球状肿块，回声不均匀。推定诊断为支持细胞肿瘤（SCT）伴隐睾。剖腹探查和切除肿块的组织学检查证实了诊断。术后3周，血清抗米勒激素（AMH）浓度从8435降至56 ng/ml，抑制素B从805降至<6 pg/ml。术后两个月，皮肤病消退，乳头肥大明显消退。本报告强调了实用程序（阴茎/包皮细胞学检查、经腹部超声检查、血清AMH和抑制素B浓度测量）对诊断隐睾和SCT的诊断价值，尤其是对全身性皮肤病患者的诊断价值。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Clinical theriogenology

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