Comparison of complications during 1-year follow-up between remitting seronegative symmetrical synovitis with pitting edema syndrome and elderly-onset rheumatoid arthritis

IF 2.7 Q3 IMMUNOLOGY
T. Origuchi, M. Umeda, T. Koga, S. Kawashiri, N. Iwamoto, K. Ichinose, M. Tamai, T. Tsukada, T. Miyashita, N. Iwanaga, Y. Horai, K. Arima, T. Aramaki, Y. Ueki, K. Eguchi, A. Kawakami
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引用次数: 2

Abstract

Abstract Remitting seronegative symmetrical synovitis with pitting edema syndrome (RS3PE), a rheumatic disease affecting the elderly, responds well to corticosteroids; however, our RS3PE patients' corticosteroid therapy is longer than expected. Elderly-onset rheumatoid arthritis (EORA) patients are reported to be at a significantly increased risk for steroid-related side effects including cardiovascular diseases (CVDs). To clarify the complications during a 1-year follow-up in corticosteroid-treated RS3PE patients compared to EORA patients. We retrospectively analyzed the records of 47 RS3PE patients (28 men, 19 women, age 78.4 ± 7.5 years) and 46 EORA patients (10 men, 36 women; 77.0 ± 6.8 yrs) to compare the complications over a 1-year follow-up. The RS3PE and EORA groups' average initial PSL doses were 16.5 ± 7.2 mg/day and 7.3 ± 4.6 mg/day, respectively. During the 1-year follow-up after treatment, there was no significant increase in CVDs in both groups. However, infections occurred in nine RS3PE patients, which is a significantly higher incidence compared to the EORA patients with infections (n = 3). The initial PSL dose was the independent variable associated with the incidence of infection. Infections were significantly increased during elderly RS3PE patients' steroid therapy. The initial corticosteroid dose was an infection-risk factor. Key messages Infections are increased during steroid therapy in elderly patients with RS3PE syndrome. The initial dose of corticosteroids was one of the risk factors for infections.
缓解血清阴性对称性滑膜炎伴点状水肿综合征与老年性类风湿关节炎1年随访期间并发症的比较
摘要缓解血清阴性对称性滑膜炎伴点蚀水肿综合征(RS3PE)是一种影响老年人的风湿性疾病,对皮质类固醇反应良好;然而,我们的RS3PE患者的皮质类固醇治疗时间比预期的要长。据报道,老年类风湿性关节炎(EORA)患者出现类固醇相关副作用(包括心血管疾病)的风险显著增加。阐明皮质类固醇治疗的RS3PE患者与EORA患者1年随访期间的并发症。我们回顾性分析了47名RS3PE患者的记录(28名男性,19名女性,年龄78.4岁) ± 7.5岁)和46名EORA患者(10名男性,36名女性;77.0 ± 6.8年)比较1年随访的并发症。RS3PE和EORA组的平均初始PSL剂量为16.5 ± 7.2 mg/天和7.3 ± 4.6mg/天。在治疗后的1年随访中,两组的心血管疾病没有显著增加。然而,感染发生在9名RS3PE患者中,与感染的EORA患者相比,这是一个显著更高的发病率(n = 3) 。PSL初始剂量是与感染发生率相关的自变量。在老年RS3PE患者的类固醇治疗期间,感染显著增加。皮质类固醇的初始剂量是感染的危险因素。关键信息RS3PE综合征老年患者在类固醇治疗期间感染增加。皮质类固醇的初始剂量是感染的危险因素之一。
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来源期刊
Immunological Medicine
Immunological Medicine Medicine-Immunology and Allergy
CiteScore
7.10
自引率
2.30%
发文量
19
审稿时长
19 weeks
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