Jiawei Sijunzi Soup Inhibits Inflammation and Oxidative Stress in the Rat Model of Diabetic Gastroparesis

IF 0.4 4区医学 Q4 NUTRITION & DIETETICS

Current Topics in Nutraceutical Research Pub Date : 2023-01-06 DOI:10.37290/ctnr2641-452x.21:80-85

Yi Zhang, Xu Wang, Yiwen Yang, Ya-qin Wei, Li Sheng, Lu Yu

引用次数: 0

Abstract

Diabetic gastroparesis is a common complication of diabetes that may lead to poor nutrition, problems managing blood glucose, and a reduced quality of life. Jiawei Sijunzi soup has been shown to benefit patients with amyotrophic lateral sclerosis while causing no serious side effects. In this study, we investigated the possible effects of Jiawei Sijunzi soup on the progression of diabetic gastroparesis in a rat model induced by streptozotocin. The results show that Jiawei Sijunzi soup reduced inflammation and oxidative stress and improved the pathological features of gastric tissue in diabetic gastroparesis. The target of Jiawei Sijunzi soup in diabetic gastroparesis was analyzed based on network pharmacology and molecular docking techniques. The results show activation of the PI3K/AKT pathway by Jiawei Sijunzi soup in the rat model of diabetic gastroparesis.

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加味四君子汤对糖尿病胃轻瘫模型大鼠炎症和氧化应激的抑制作用

糖尿病胃轻瘫是糖尿病的常见并发症，可能导致营养不良、血糖管理问题和生活质量下降。加味四君子汤已被证明对肌萎缩侧索硬化症患者有益，但不会产生严重的副作用。在本研究中，我们研究了加味四君子汤对链脲佐菌素诱导的大鼠糖尿病胃轻瘫进展的可能影响。结果表明，加味四君子汤能减轻糖尿病胃轻瘫患者的炎症和氧化应激，改善胃组织的病理特点。运用网络药理学和分子对接技术，对加味四君子汤治疗糖尿病胃轻瘫的作用靶点进行了分析。结果显示加味四君子汤在糖尿病胃轻瘫大鼠模型中激活PI3K/AKT通路。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Current Topics in Nutraceutical Research 医学-药学

CiteScore

1.10

自引率

0.00%

发文量

审稿时长

>12 weeks

期刊介绍： Current Topics in Nutraceutical Research is an international, interdisciplinary broad-based peer reviewed scientific journal for critical evaluation of research on chemistry, biology and therapeutic applications of nutraceuticals and functional foods. The major goal of this journal is to provide peer reviewed unbiased scientific data to the decision makers in the nutraceutical and food industry to help make informed choices about development of new products. To this end, the journal will publish two types of review articles. First, a review of preclinical research data coming largely from animal, cell culture and other experimental models. Such data will provide basis for future product development and/or human research initiatives. Second, a critical evaluation of current human experimental data to help market and deliver the product for medically proven use. This journal will also serve as a forum for nutritionists, internists, neurologists, psychiatrists, and all those interested in preventive medicine. The common denominator of all of the topic to be covered by the journal must include nutraceuticals and/functional food. The following is an example of some specific areas that may be of interest to the journal. i) Role of vitamins, minerals, antioxidants and phytonutrients on cardiovascular health, cancer, diabetes, ocular health, mental health, men’s health, women’s health, infant nutrition, ii) Role of herbals on human health, iii) Dietary supplements and sleep, iv) Components of diet that may have beneficial effect on human health, v) regulation of apoptosis and cell viability, vi) Isolation and characterization of bioactive components from functional foods, vii) Nutritional genomics, and viii) Nutritional proteomics.