Combination of Oxalobacter Formigenes and Veillonella Parvula in Gastrointestinal Microbiota Related to Bile-Acid Metabolism as a Biomarker for Hypertensive Nephropathy

IF 1.9 4区医学 Q3 PERIPHERAL VASCULAR DISEASE

International Journal of Hypertension Pub Date : 2022-05-17 DOI:10.1155/2022/5999530

Xin Li, Li Wang, Shaojun Ma, Shaohui Lin, Chunyan Wang, Hai-yun Wang

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引用次数: 2

Abstract

The human microbiome is a mixed group of microorganisms, which individually consists of 10–100 trillion symbiotic microbial cells. The relationship between gastrointestinal microbiota and blood pressure has been verified and the intestinal microbiota of chronic kidney disease (CKD) patients in the distribution of bacterial species is different from the flora of people with no CKD. The purpose of this research is to study the different intestinal microbiota of hypertensive patients with and without nephropathy and to find possible biomarkers of hypertensive nephropathy (H-CKD). The subjects of this research were divided into three groups, healthy control group, hypertension group, and hypertensive nephropathy group. Sequencing, bioinformatics, and statistical analysis were performed on the 16S rRNA gene of the subjects' stool samples. This research study showed the differences of intestinal flora as biomarkers in hypertension patients with and without nephropathy; it investigated the relationship of the differences in the intestinal microbiota with bile-acid metabolism; it also explored bile-acid metabolism mechanism of intestinal microbiota differences in hypertension with or without nephropathy. In summary, the difference in the combination of O. formigenes and V. parvula in the gastrointestinal microbiota is related to bile-acid metabolism in hypertensive patients and can be one of the factors causing CKD. It is the first time to report such a biomarker or pathogenic factor of H-CKD in the world.

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与胆汁酸代谢相关的胃肠道微生物群中Formigenes草酸杆菌和小叶细络菌的联合作为高血压肾病的生物标志物

人类微生物组是一组混合的微生物，由10–100万亿个共生微生物细胞组成。胃肠道微生物群与血压之间的关系已经得到证实，慢性肾脏病（CKD）患者的肠道微生物群在细菌种类分布上与非CKD患者的菌群不同。本研究的目的是研究患有和不患有肾病的高血压患者的不同肠道微生物群，并寻找可能的高血压肾病（H-CKD）的生物标志物。本研究将受试者分为三组，健康对照组、高血压组和高血压肾病组。对受试者粪便样本的16S rRNA基因进行测序、生物信息学和统计分析。这项研究显示了有肾病和无肾病的高血压患者肠道菌群作为生物标志物的差异；研究了肠道微生物群的差异与胆汁酸代谢的关系；探讨了高血压合并或不合并肾病时肠道微生物群差异的胆汁酸代谢机制。总之，在胃肠道微生物群中，变形杆菌和细小病毒组合的差异与高血压患者的胆汁酸代谢有关，可能是导致CKD的因素之一。这是世界上第一次报道这种H-CKD的生物标志物或致病因子。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

International Journal of Hypertension Medicine-Internal Medicine

CiteScore

4.00

自引率

5.30%

发文量

期刊介绍： International Journal of Hypertension is a peer-reviewed, Open Access journal that provides a forum for clinicians and basic scientists interested in blood pressure regulation and pathophysiology, as well as treatment and prevention of hypertension. The journal publishes original research articles, review articles, and clinical studies on the etiology and risk factors of hypertension, with a special focus on vascular biology, epidemiology, pediatric hypertension, and hypertensive nephropathy.