Antibacterial activity of soil-isolated Bacillus altitudinis/pumilus complex against methicillin-resistant Staphylococcus aureus from Mwanza, Tanzania.

IF 1 Q4 MEDICINE, RESEARCH & EXPERIMENTAL

African Journal of Laboratory Medicine Pub Date : 2023-07-18 eCollection Date: 2023-01-01 DOI:10.4102/ajlm.v12i1.2167

Reuben N Abednego, Vitus Silago

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Abstract

Antimicrobial resistance in methicillin-resistant Staphylococcus aureus and beta-lactamase-producing Gram-negative bacteria is a global health concern necessitating research and the development of effective antimicrobial agents. This study, conducted in May 2020 in Mwanza, Tanzania, aimed to determine the antibacterial activity of metabolites from soil-isolated Bacillus species against clinical bacterial pathogens. One soil-isolated Bacillus species, identified as Bacillus altitudinis/pumilus complex, showed antibacterial activity against Gram-positive cocci, including a methicillin-resistant S. aureus strain with inducible clindamycin resistance, previously isolated from a patient with osteomyelitis. Bacillus altitudinis/pumilus complex metabolites may be a potential source of antimicrobial agents against multidrug-resistant bacteria.

What this study adds: The study supports existing research on the discovery and development of new antimicrobial agents against multi-drug-resistant bacteria. We report the antimicrobial activity of metabolites extracted from soil-isolated Bacillus altitudinis/pumilus complex strains against Gram-positive bacteria, including a methicillin-resistant Staphylococcus aureus strain with inducible clindamycin resistance.

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土壤分离的高原芽孢杆菌/矮孢杆菌复合体对坦桑尼亚姆万扎耐甲氧西林金黄色葡萄球菌的抑菌活性

耐甲氧西林金黄色葡萄球菌和产β-内酰胺酶的革兰氏阴性菌的耐药性是一个全球性的健康问题，需要研究和开发有效的抗菌剂。这项研究于2020年5月在坦桑尼亚姆万扎进行，旨在确定土壤分离的芽孢杆菌代谢产物对临床细菌病原体的抗菌活性。一种土壤分离的芽孢杆菌，被鉴定为高原芽孢杆菌/浮石复合物，对革兰氏阳性球菌表现出抗菌活性，包括一种耐甲氧西林的S。具有诱导型克林霉素耐药性的金黄色葡萄球菌菌株，先前从骨髓炎患者中分离。高原芽孢杆菌/浮木复合代谢产物可能是对抗多重耐药细菌的抗菌剂的潜在来源。这项研究补充道：这项研究支持了现有的研究，即发现和开发针对多种耐药细菌的新型抗菌剂。我们报道了从土壤分离的高原芽孢杆菌/浮石复合菌株中提取的代谢产物对革兰氏阳性菌的抗菌活性，包括一株具有诱导型克林霉素耐药性的耐甲氧西林金黄色葡萄球菌菌株

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来源期刊

African Journal of Laboratory Medicine MEDICINE, RESEARCH & EXPERIMENTAL-

CiteScore

1.70

自引率

9.10%

发文量

审稿时长

12 weeks

期刊介绍： The African Journal of Laboratory Medicine, the official journal of ASLM, focuses on the role of the laboratory and its professionals in the clinical and public healthcare sectors,and is specifically based on an African frame of reference. Emphasis is on all aspects that promote and contribute to the laboratory medicine practices of Africa. This includes, amongst others: laboratories, biomedical scientists and clinicians, medical community, public health officials and policy makers, laboratory systems and policies (translation of laboratory knowledge, practices and technologies in clinical care), interfaces of laboratory with medical science, laboratory-based epidemiology, laboratory investigations, evidence-based effectiveness in real world (actual) settings.