Quantifying Enlargement of Brain Cerebrospinal Fluid Spaces: A Differential Equation Approach to Clinical Outcome in Melancholia

Q3 Medicine

Neurology Psychiatry and Brain Research Pub Date : 2020-12-01 DOI:10.1016/j.npbr.2020.10.005

Anisha Das

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Abstract

The physiological processes involved in cognitive neurology are highly complex, spanning a wide range of inter-related temporal and spatial scales. The complexity of relationship between brain cerebrospinal fluid (CSF) space changes and patient prognosis in melancholic depression is well suited to quantitative approaches as it provides challenges and opportunities for new developments. The purpose of this article is to come up with present mathematical trends in the clinical outcome of depressive patients, which can trigger off challenges that lie in the field ahead. To be more specific, mathematical models have been the main focus in the study, that are capable of addressing critical questions associated with intracranial neoplasms and brain tumours, their growth and patient-specific differential diagnosis. Also, the explicit interactions between the brain-delivered neurotrophic factor (BDNF) Val66Met gene and early-life stress (ELS) exposure in brain have been established through differential equation models.

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量化扩大脑-脑脊液间隙：用微分方程方法评价忧郁症的临床疗效

认知神经学涉及的生理过程是高度复杂的，跨越了广泛的相互关联的时间和空间尺度。抑郁症患者脑脊液(CSF)空间变化与预后关系的复杂性非常适合定量方法，因为它为新的发展提供了挑战和机遇。本文的目的是提出目前抑郁症患者临床结果的数学趋势，这可以引发未来领域的挑战。更具体地说，数学模型一直是这项研究的主要焦点，它能够解决与颅内肿瘤和脑肿瘤、它们的生长和患者特异性鉴别诊断相关的关键问题。此外，通过微分方程模型建立了脑传递神经营养因子(BDNF) Val66Met基因与脑早期生活应激(ELS)暴露之间的显式相互作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Neurology Psychiatry and Brain Research 医学-精神病学

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期刊介绍： Neurology, Psychiatry & Brain Research publishes original papers and reviews in biological psychiatry, brain research, neurology, neuropsychiatry, neuropsychoimmunology, psychopathology, psychotherapy. The journal has a focus on international and interdisciplinary basic research with clinical relevance. Translational research is particularly appreciated. Authors are allowed to submit their manuscript in their native language as supplemental data to the English version. Neurology, Psychiatry & Brain Research is related to the oldest German speaking journal in this field, the Centralblatt fur Nervenheilkunde, Psychiatrie und gerichtliche Psychopathologie, founded in 1878. The tradition and idea of previous famous editors (Alois Alzheimer and Kurt Schneider among others) was continued in modernized form with Neurology, Psychiatry & Brain Research. Centralblatt was a journal of broad scope and relevance, now Neurology, Psychiatry & Brain Research represents a journal with translational and interdisciplinary perspective, focusing on clinically oriented research in psychiatry, neurology and neighboring fields of neurosciences and psychology/psychotherapy with a preference for biologically oriented research including basic research. Preference is given for papers from newly emerging fields, like clinical psychoimmunology/neuroimmunology, and ideas.