Severe hypoglycemia and falls in older adults with diabetes: The Diabetes & Aging Study

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Accounts of Chemical Research Pub Date : 2023-10-01 DOI:10.1016/j.deman.2023.100162

Howard H. Moffet , Elbert S. Huang , Jennifer Y. Liu , Melissa M. Parker , Kasia J. Lipska , Neda Laiteerapong , Richard W. Grant , Alexandra K. Lee , Andrew J. Karter

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Abstract

Objective

To estimate rates of severe hypoglycemia and falls among older adults with diabetes and evaluate their association.

Research Design and Methods

Survey in an age-stratified, random sample adults with diabetes age 65–100 years; respondents were asked about severe hypoglycemia (requiring assistance) and falls in the past 12 months. Prevalence ratios (adjusted for age, sex, race/ethnicity) estimated the increased risk of falls associated with severe hypoglycemia.

Results

Among 2,158 survey respondents, 79 (3.7%) reported severe hypoglycemia, of whom 68 (86.1%) had no ED visit or hospitalization for hypoglycemia. Falls were reported by 847 (39.2%), of whom 745 (88.0%) had no fall documented in outpatient or inpatient records. Severe hypoglycemia was associated with a 70% greater prevalence of falls (adjusted prevalence ratio = 1.7 (95% CI, 1.3–2.2)).

Conclusion

While clinical documentation of events likely reflects severity or care-seeking behavior, severe hypoglycemia and falls are common, under-reported life-threatening events.

Abstract Image

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老年糖尿病患者的严重低血糖和跌倒:糖尿病与衰老研究

目的评估老年糖尿病患者的严重低血糖和跌倒发生率，并评价其相关性。研究设计与方法对年龄分层、随机抽样的65-100岁成人糖尿病患者进行调查;受访者被问及在过去12个月内是否有严重低血糖(需要帮助)和跌倒的情况。流行率(根据年龄、性别、种族/民族进行调整)估计与严重低血糖相关的跌倒风险增加。结果2158名调查对象中，79人(3.7%)报告有严重低血糖，其中68人(86.1%)未因低血糖而就诊或住院。847人(39.2%)报告跌倒，其中745人(88.0%)在门诊或住院记录中没有跌倒记录。严重低血糖与跌倒发生率增加70%相关(校正患病率= 1.7 (95% CI, 1.3-2.2))。结论:虽然事件的临床记录可能反映了严重程度或求医行为，但严重低血糖和跌倒是常见的，未被报道的危及生命的事件。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.