Silica Gel Functionalized with Polyethylenimine as Advanced Sorbents for the Removal of Endotoxin from Gelatin

IF 4.4 2区化学 Q2 MATERIALS SCIENCE, MULTIDISCIPLINARY

ACS Applied Polymer Materials Pub Date : 2023-04-27 DOI:10.1021/acsapm.3c00055

Weijie Zhang, Bing Zhang*, Jianing Wang, Yihu Wang, Xiaofeng Cao, Weipeng Lu and Yanchuan Guo*,

引用次数: 0

Abstract

Gelatin is one of the essential materials for tissue engineering for its unique physicochemical properties. The endotoxin in gelatin needs to be controlled at a reasonable level to guarantee biosafety when applied to the human body. However, the isothermal titration calorimetry results showed specific interactions between gelatin and endotoxin, suggesting the difficulties of removing endotoxin from gelatin in mild conditions. In this work, a polyethyleneimine-grafted silica gel adsorbent for endotoxin was designed and prepared. Results showed that the prepared endotoxin adsorbent could remove endotoxin from gelatin without significantly changing the structures and properties of gelatin.

Abstract Image

查看原文本刊更多论文

聚乙烯亚胺功能化硅胶作为去除明胶内毒素的高级吸附剂

明胶以其独特的理化性质成为组织工程的重要材料之一。明胶中的内毒素需要控制在合理的水平，以保证应用于人体时的生物安全性。然而，等温滴定量热法结果显示明胶和内毒素之间存在特定的相互作用，这表明在温和条件下从明胶中去除内毒素是困难的。本文设计并制备了一种聚乙烯亚胺接枝硅胶内毒素吸附剂。结果表明，所制备的内毒素吸附剂可以去除明胶中的内毒素，而不会显著改变明胶的结构和性质。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

ACS Applied Polymer Materials Multiple-

CiteScore

7.20

自引率

6.00%

发文量

810

期刊介绍： ACS Applied Polymer Materials is an interdisciplinary journal publishing original research covering all aspects of engineering, chemistry, physics, and biology relevant to applications of polymers. The journal is devoted to reports of new and original experimental and theoretical research of an applied nature that integrates fundamental knowledge in the areas of materials, engineering, physics, bioscience, polymer science and chemistry into important polymer applications. The journal is specifically interested in work that addresses relationships among structure, processing, morphology, chemistry, properties, and function as well as work that provide insights into mechanisms critical to the performance of the polymer for applications.