Dynamic Changes of Cardiac Biomarkers in Non-ST-elevation Myocardial Infarction

Q4 Medicine

Journal of the Hong Kong College of Cardiology Pub Date : 2018-10-01 DOI:10.55503/2790-6744.1011

M. Nabati, Bahareh Golestani, J. Yazdani, Mozhdeh Dabirian, Homa Parsaee

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Abstract

NABATI ET AL: Dynamic Changes of Cardiac Biomarkers in Non-ST-elevation Myocardial Infarction: Objective: Creatine kinase-myocardial band (CK-MB) and troponin-I are the most specific and accurate indicators of myocardial infarction among different cardiac biomarkers. However, few studies have examined the correlation between temporal changes of these biomarkers and high risk echocardiographic and angiographic variables. The aim of our study was to assess the relationship between these variables. Methods: Our study was a prospective study of 113 patients with a diagnosis of non-ST-elevation myocardial infarction (NSTEMI) who were admitted within the first hours of the onset of chest pain. Troponin-I and CK-MB were measured serially at the time of hospital admission, at 6-9 hours and again at 12-24 hours. All patients underwent transthoracic echocardiography and coronary angiography and left ventricular ejection fraction (LVEF), mitral regurgitation and severity of coronary artery disease were determined. Results: Troponin-I level within 6-9 hours after admission was significantly associated with significant coronary artery disease among different variables (P-value=0.032, odds ratio=1.11, 95% confidence interval [1.01-1.22]). Also, patients younger than 65 years of age had higher levels of troponin-I within 6-9 and 12-24

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非ST段抬高型心肌梗死心脏生物标志物的动态变化

NABATI ET AL：非ST段抬高型心肌梗死中心脏生物标志物的动态变化：目的：肌酸激酶心肌带（CK-MB）和肌钙蛋白I是不同心脏生物标志中最特异、最准确的心肌梗死指标。然而，很少有研究检测这些生物标志物的时间变化与高危超声心动图和血管造影变量之间的相关性。我们研究的目的是评估这些变量之间的关系。方法：我们的研究对113名诊断为非ST段抬高型心肌梗死（NSTEMI）的患者进行了前瞻性研究，这些患者在胸痛发作后的最初几个小时内入院。在入院时、6-9小时和12-24小时连续测量肌钙蛋白I和CK-MB。所有患者均接受了经胸超声心动图和冠状动脉造影，并测定了左心室射血分数（LVEF）、二尖瓣反流和冠状动脉疾病的严重程度。结果：在不同的变量中，入院后6-9小时内的肌钙蛋白I水平与严重的冠状动脉疾病显著相关（P值=0.032，比值比=1.11，95%置信区间[1.01-1.22]）。此外，65岁以下的患者在6-9和12-24小时内肌钙蛋白I水平较高

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来源期刊

Journal of the Hong Kong College of Cardiology Medicine-Cardiology and Cardiovascular Medicine

CiteScore

0.30

自引率

0.00%

发文量

期刊介绍： The Journal of the Hong Kong College of Cardiology publishes peer-reviewed articles on all aspects of cardiovascular disease, including original clinical studies, review articles and experimental investigations. As official journal of the Hong Kong College of Cardiology, the journal publishes abstracts of reports to be presented at the Scientific Sessions of the College as well as reports of the College-sponsored conferences.