IMPROVING CONTROL STRATEGIES OF INFECTIONS BY RESISTANT PATHOGENS IN A HOSPITAL NETWORK

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Accounts of Chemical Research Pub Date : 2023-05-06 DOI:10.1142/s0218339023500262

T. Vilches, G. B. de Almeida, C.M.C.B. Fortaleza, C. Ferreira

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Abstract

The efficacy of infection prevention and control on several hospital networks is assessed. We tested two kinds of strategy, a network-topology-based allocation and a [Formula: see text]-based allocation, where [Formula: see text] is the basic reproduction number of the infection. For this, a multi-patch deterministic model simulates the spread of carbapenemase-producing Enterobacteriaceae in several theoretical hospital networks parametrized by data from Brazil. Our results show that: (i) the allocation methods based on the [Formula: see text] of the hospitals may work better than the network-topology-based allocations; (ii) results from control efficacy for a specific hospital network cannot be generalized to other types of networks. Putting together the global network topology with local factors that drive pathogens transmission, the [Formula: see text]-based allocation method seems to be enough to control of healthcare-associated infections. Overall, the obtained results emphasize the importance of data collection on infection transmission and patient transfers.

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改进医院网络中耐药病原体感染的控制策略

评估了几家医院网络的感染预防和控制效果。我们测试了两种策略，一种是基于网络拓扑的分配，另一种是基于[公式:见文本]的分配，其中[公式:见文本]是感染的基本繁殖数。为此，一个多斑块确定性模型模拟了产碳青霉烯酶肠杆菌科在巴西数据参数化的几个理论医院网络中的传播。研究结果表明:(1)基于医院[公式:见文本]的分配方法可能比基于网络拓扑的分配方法效果更好;(ii)对特定医院网络的控制效果的结果不能推广到其他类型的网络。将全球网络拓扑结构与驱动病原体传播的局部因素结合起来，基于[公式:见文本]的分配方法似乎足以控制与医疗保健相关的感染。总的来说，获得的结果强调了收集感染传播和患者转移数据的重要性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.