Glass-based coatings on biomedical implants: a state-of-the-art review

Q1 Materials Science

Biomedical Glasses Pub Date : 2017-04-25 DOI:10.1515/bglass-2017-0001

F. Baino, E. Verné

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引用次数: 69

Abstract

Abstract Bioactive glasses, invented by Prof. Larry L. Hench in the late 1960s, have revolutionized the field of biomaterials as they were shown to tightly bond to both hard and soft living tissues and to stimulate cells towards a path of regeneration and self-repair. However, due to their relatively poor mechanical properties (brittleness, low bending strength and fracture toughness), they are generally unsuitable for load-bearing applications. On the other hand, bioactive glasses have been successfully applied as coatings on the surface of stronger/tougher substrates to combine adequate mechanical properties with high bioactivity and, in some cases, additional extrafunctionalities (e.g. antibacterial properties, drug release). After giving a short overview of the main issues concerning the fabrication of glass coatings, this review provides a state-of-the-art picture in the field and specifically discusses the development of bioactive and hierarchical coatings on 3D porous scaffolds, joint prostheses, metallic substrates (e.g. wires or nails) for orthopedic fixation, polymeric meshes and sutures for wound healing, ocular implants and percutaneous devices.

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生物医学植入物上的玻璃基涂层：最新进展

摘要拉里·L·亨奇教授在20世纪60年代末发明的生物活性玻璃彻底改变了生物材料领域，因为它们被证明可以与硬组织和软组织紧密结合，并刺激细胞走向再生和自我修复的道路。然而，由于其相对较差的机械性能（脆性、低弯曲强度和断裂韧性），它们通常不适合承载应用。另一方面，生物活性玻璃已成功地作为涂层应用于更强/更坚韧的基底表面，以将足够的机械性能与高生物活性结合起来，在某些情况下，还具有额外的额外功能（如抗菌性能、药物释放）。在简要概述了玻璃涂层制造的主要问题后，这篇综述提供了该领域的最新情况，并具体讨论了在3D多孔支架、关节假体、用于骨科固定的金属基底（如金属丝或钉子）、用于伤口愈合的聚合网片和缝线上开发生物活性和分级涂层，眼部植入物和经皮装置。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Biomedical Glasses Materials Science-Surfaces, Coatings and Films

自引率

0.00%

发文量

审稿时长

17 weeks

期刊介绍： Biomedical Glasses is an international Open Access-only journal covering the field of glasses for biomedical applications. The scope of the journal covers the science and technology of glasses and glass-based materials intended for applications in medicine and dentistry. It includes: Chemistry, physics, structure, design and characterization of biomedical glasses Surface science and interactions of biomedical glasses with aqueous and biological media Modeling structure and reactivity of biomedical glasses and their interfaces Biocompatibility of biomedical glasses Processing of biomedical glasses to achieve specific forms and functionality Biomedical glass coatings and composites In vitro and in vivo evaluation of biomedical glasses Glasses and glass-ceramics in engineered regeneration of tissues and organs Glass-based devices for medical and dental applications Application of glasses and glass-ceramics in healthcare.