Western Desert region between Cairo and Fayoum in Egypt is a geologically interesting area due to its active seismicity status and the continuous bidirectional urban expansions ongoing northward and southward growth. This work aims to develop a geological model of the region by combining magnetic intensity data (aeromagnetic) and potential field data (airborne gravity) with magnetotelluric (MT) data to offer decision-makers an additional evaluation tool for long-term future planning. Applying a number of filters to aerial gravity and magnetic data allowed us to calculate the subsurface density distribution and structure of the area between Cairo and Fayoum. In addition, the surface of the crust was imaged down to a depth of 6 km using a 3-D inversion of gravity data. Magnetotelluric data were gathered at eight locations over the NS-extended Cairo-Fayoum Road profile. MT data were inverted in 2-D to generate a resistivity model that defines the subsurface structure of the researched region. The subsurface geometry in the MT-derived resistivity model agrees with the results of airborne potential measurements, and no consideration was given to any faults that may have been undetected from the potential maps. Long-term seismological observations indicated that the likely active sources of earthquakes are limited to the recognized main faults and that the ongoing “1185 buildings” construction project did not and will not cause unanticipated seismicity. The paper concludes that urban growth is secure so long as the earthquake codes are rigorously considered while planning civil projects. The northern study region must be regularly monitored for induced seismicity. On the Cairo-Fayoum Road's western side, the middle sector of the study area is the safest place for future civil developments.