Profile of maternal serum oxytocin in postpartum and non-pregnant rats

Q3 Veterinary

Veterinarska stanica Pub Date : 2023-05-31 DOI:10.46419/vs.54.6.8

B. A. Tjokroprawiro, M. I. Aldika Akbar, E. Luqman, Widjiati Widijati

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引用次数: 0

Abstract

Oxytocin is primarly secreted in the brain as a neuromodulator that affects numerous neurophysiological and behavioral processes. It is also produced in the ovaries and uterus to stimulate delivery and lactation. Oxytocin mRNA is found in the endometrial epithelial cells of non-pregnant women during ovulation and menstruation. Until recently, there have been no data on scientific-level oxytocin in virgin female rats. This study aimed to compare the level of oxytocin in different physical biology between postpartum and non-pregnant experimental animals (virgin or had never given birth). This experimental study was conducted on 19 female white rats (Rattus norvegicus) allocated to two groups: T1 and T2. The ten rats in group T1 (nulliparous virgin) and the nine in group T2 (postpartum) were sacrificed on day two, except for group T1, which were sacrificed following vaginal delivery. Blood was collected intracardiacally, and serum oxytocin levels were evaluated using an ELISA assay. The T-test was used for statistical data analysis. The serum oxytocin level in the T2 group (628.06 ± 168.72 pg/mL) was significantly higher than in the T1 group (366.71 ± 185.03 pg/mL; P < 0.05). In conclusion, oxytocin levels were higher in postpartum animals than in virgin animals. Thus, oxytocin plays a greater role in female reproduction than in normal physiological condition.

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产后和非妊娠大鼠母体血清催产素的变化

催产素主要作为一种神经调节剂分泌在大脑中，影响许多神经生理学和行为过程。它也在卵巢和子宫中产生，以刺激分娩和哺乳。催产素信使核糖核酸在非妊娠妇女排卵和月经期间的子宫内膜上皮细胞中发现。直到最近，还没有关于处女雌性大鼠的科学水平催产素的数据。本研究旨在比较产后和未怀孕实验动物（处女或从未分娩）在不同物理生物学中的催产素水平。本实验研究在19只雌性大鼠（褐家鼠）身上进行，它们被分为两组：T1和T2。除T1组在阴道分娩后处死外，T1组（未产妇）的10只大鼠和T2组（产后）的9只大鼠在第二天处死。在心脏内采集血液，并使用ELISA测定法评估血清催产素水平。T检验用于统计数据分析。T2组的血清催产素水平（628.06±168.72 pg/mL）显著高于T1组（366.71±185.03 pg/mL；P<0.05）。因此，催产素在女性生殖中的作用比在正常生理条件下更大。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Veterinarska stanica Veterinary-Veterinary (all)

CiteScore

1.10

自引率

0.00%

发文量

期刊介绍： The goal of the journal is to provide an international platform for the publication of articles in the fields of veterinary and animal sciences, and biotechnology. The content of the journal is particularly dedicated to veterinary practitioners, but also to veterinary scientists and university professors, to encourage them to share their knowledge and experience on this platform. Manuscripts submitted to the journal may include: original scientific papers, review articles, short communications, professional articles, case reports, conference reports and literary records and reviews of new book either in Croatian or English languages.