Ethylmethylhydroxypyridine succinate, acetylcysteine and choline alphoscerate improve mitochondrial function under condition of cerebral ischemia in rat

IF 0.9 4区医学 Q4 PHARMACOLOGY & PHARMACY

Bangladesh Journal of Pharmacology Pub Date : 2019-08-28 DOI:10.3329/bjp.v14i3.40977

Pozdnyakov Dmitry, Nygaryan A. Syranusch, V. Andrey, A. Sosnovskaya, Cherechkova I. Elisaveta

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引用次数: 2

Abstract

The study was devoted to see the effect of ethylmethylhydroxypyridine succinate, acetylcysteine and choline alphoscerate on the mitochondrial function under condition of experimental cerebral ischemia in rat. An integrated approach was used with the assessment of changes in the respirometric and antiapoptotic functions of mitochondria. It was found that the application of the objects under study contributed to a decrease in the intensity of glycolysis and the restoration of aerobic glucose metabolism with an increase in ATP synthesis, as well as a decrease in the dissociation of reactions in mitochondrial complexes I, II, IV and V. In addition, the introduction of the studied drugs reduced the intensity of caspase-dependent and caspase-independent apoptosis reactions, which, together with the restoration of mitochondrial respiratory function, contributed to the decrease in the size of the necrosis zone of the brain. Video Clip of Methodology: Rat middle cerebral artery occlusion: 8 min 7 sec Full Screen Alternate

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丁二酸乙基甲基羟吡啶、乙酰半胱氨酸和胆碱α脂酸对脑缺血大鼠线粒体功能的改善作用

本研究观察了琥珀酸酯、乙酰半胱氨酸和磷酸胆碱对大鼠实验性脑缺血条件下线粒体功能的影响。采用综合方法评估线粒体呼吸和抗凋亡功能的变化。研究发现，所研究对象的应用有助于降低糖酵解的强度，并随着ATP合成的增加而恢复有氧葡萄糖代谢，以及减少线粒体复合物I、II、IV和V中反应的解离。此外，所研究药物的引入降低了caspase依赖性和caspase非依赖性细胞凋亡反应的强度，这与线粒体呼吸功能的恢复一起，有助于减少大脑坏死区的大小。方法学视频剪辑：大鼠大脑中动脉闭塞：8分7秒全屏交替

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来源期刊

Bangladesh Journal of Pharmacology PHARMACOLOGY & PHARMACY-

CiteScore

1.50

自引率

18.80%

发文量

审稿时长

>12 weeks

期刊介绍： Bangladesh Journal of Pharmacology (Bangladesh J Pharmacol) is an open access, video component, peer-reviewed journal of the Bangladesh Pharmacological Society (BDPS). A scholarly publication is defined ''open access'' when there are no financial, legal or technical barriers to accessing it. Anyone can read, download, copy, distribute, print or use it in educational purpose within the legal agreements. Peer review of a manuscript means the evaluation of research work by one or more people with similar competences. It can be open or blind. We do the single-blind peer review. Our readers want to know the methodology used by the researchers which is very important to get the results. The video clip of one of the methodologies is prepared by the authors and submit it to publish.