Genetic and Molecular Determinants of Lymphatic Malformations: Potential Targets for Therapy

IF 2.2 Q3 DEVELOPMENTAL BIOLOGY

Journal of Developmental Biology Pub Date : 2022-02-08 DOI:10.3390/jdb10010011

Su Yeon Lee, E. Loll, A. Hassan, Mingyu Cheng, Aijun Wang, D. Farmer

引用次数: 5

Abstract

Lymphatic malformations are fluid-filled congenital defects of lymphatic channels occurring in 1 in 6000 to 16,000 patients. There are various types, and they often exist in conjunction with other congenital anomalies and vascular malformations. Great strides have been made in understanding these malformations in recent years. This review summarize known molecular and embryological precursors for lymphangiogenesis. Gene mutations and dysregulations implicated in pathogenesis of lymphatic malformations are discussed. Finally, we touch on current and developing therapies with special attention on targeted biotherapeutics.

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淋巴畸形的遗传和分子决定因素:治疗的潜在目标

淋巴畸形是一种充满液体的先天性淋巴通道缺陷，在6000至16000名患者中发生。有多种类型，它们通常与其他先天性异常和血管畸形一起存在。近年来，在理解这些畸形方面取得了巨大的进步。本文综述了已知的淋巴管生成的分子和胚胎学前体。基因突变和失调涉及的发病机制淋巴畸形进行了讨论。最后，我们谈到了目前和正在发展的治疗方法，特别关注靶向生物疗法。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Developmental Biology Biochemistry, Genetics and Molecular Biology-Developmental Biology

CiteScore

4.10

自引率

18.50%

发文量

审稿时长

11 weeks

期刊介绍： The Journal of Developmental Biology (ISSN 2221-3759) is an international, peer-reviewed, quick-refereeing, open access journal, which publishes reviews, research papers and communications on the development of multicellular organisms at the molecule, cell, tissue, organ and whole organism levels. Our aim is to encourage researchers to effortlessly publish their new findings or concepts rapidly in an open access medium, overseen by their peers. There is no restriction on the length of the papers; the full experimental details must be provided so that the results can be reproduced. Electronic files regarding the full details of the experimental procedure, if unable to be published in a normal way, can be deposited as supplementary material. Journal of Developmental Biology focuses on: -Development mechanisms and genetics -Cell differentiation -Embryonal development -Tissue/organism growth -Metamorphosis and regeneration of the organisms. It involves many biological fields, such as Molecular biology, Genetics, Physiology, Cell biology, Anatomy, Embryology, Cancer research, Neurobiology, Immunology, Ecology, Evolutionary biology.