Remdesivir: an overview of patenting trends, clinical evidence on COVID-19 treatment, pharmacology and chemistry.

IF 1.8 Q3 PHARMACOLOGY & PHARMACY
Sandro G Viveiros Rosa, W. C. Santos
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引用次数: 2

Abstract

By December 2021, the COVID-19 caused approximately 6.1 million deaths around the world. Several vaccines have been approved, but there is still a need for non-prophylactic treatments for COVID-19. Remdesivir is an antiviral drug approved for emergency use against COVID-19 in several countries, but one of the first clinical trials was inconclusive about the mortality reduction, although the drug showed a reduction in the recovery time of hospitalized patients. Thus, the present investigation revisits the clinical evidence of using remdesivir for COVID-19 treatment, patent status, pharmacology and chemistry. We found 184 families of patents in the Cortellis database, and concerning the clinical evidence, we retrieved 14 systematic reviews with meta-analysis involving remdesivir as a treatment for COVID-19, discussing the reduction of adverse events, hospitalization days, mortality rate and the mechanical ventilation period.
瑞德西韦:新冠肺炎治疗的专利趋势、临床证据、药理学和化学综述。
截至2021年12月,新冠肺炎在全球造成约610万人死亡。一些疫苗已经获得批准,但仍需要对新冠肺炎进行非预防性治疗。Remdesivir是一种抗病毒药物,在几个国家被批准紧急用于治疗新冠肺炎,但首批临床试验之一对降低死亡率没有结论,尽管该药物显示住院患者的恢复时间缩短。因此,本研究重新审视了使用瑞德西韦治疗新冠肺炎的临床证据、专利状况、药理学和化学。我们在Cortellis数据库中发现了184个专利家族,关于临床证据,我们检索了14篇涉及瑞德西韦治疗新冠肺炎的系统综述和荟萃分析,讨论了不良事件的减少、住院天数、死亡率和机械通气期。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Pharmaceutical patent analyst
Pharmaceutical patent analyst PHARMACOLOGY & PHARMACY-
CiteScore
1.80
自引率
0.00%
发文量
22
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