Prevalence and Antimicrobial Resistance of Bloodstream Infections Caused by ESKAPEEc Pathogens: A Five-year Analysis

IF 0.5 4区医学 Q4 MICROBIOLOGY

Jundishapur Journal of Microbiology Pub Date : 2022-08-13 DOI:10.5812/jjm-122990

A. Yardimci, D. Arman

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引用次数: 1

Abstract

Background: Antimicrobial resistance in ESKAPEEc (Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa, Enterobacter species, and Escherichia coli) pathogens causing bloodstream infections (BSIs) is a growing threat to clinicians and public health. Objectives: Our purpose was to determine the prevalence and susceptibility of ESKAPEEcs causing BSI over five years (2016 to 2020) at a large tertiary hospital in Istanbul, Turkey. Methods: Of 2591 unique isolates obtained from blood culture specimens, 1.281 (49.4%) were positive for ESKAPEEc pathogens. The ESKAPEEc rates increased from 2016 to 2019 and decreased during the COVID-19 pandemic. Results: The most common pathogen was K. pneumoniae (34.3%). Carbapenem resistant (CR) K. pneumoniae was 61.8% and A. baumannii was 90.4%. The percentages of methicillin-resistant S. aureus (MRSA) and vancomycin-resistant E. faecium (VRE) were 38.6% and 29.4%, respectively. Conclusions: Our findings showed a high incidence of ESKAPEEc and AMR in BSIs. Antibiotic policies and restrictions in health care settings and the community will play an essential role in the solution in the future.

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ESKAPEEc病原菌引起的血流感染的患病率和耐药性:一项为期五年的分析

背景：引起血液感染（BSI）的ESKAPEEc（粪肠球菌、金黄色葡萄球菌、肺炎克雷伯菌、鲍曼不动杆菌、铜绿假单胞菌、肠杆菌属和大肠杆菌）病原体的耐药性对临床医生和公众健康构成了越来越大的威胁。目的：我们的目的是确定土耳其伊斯坦布尔一家大型三级医院五年（2016年至2020年）内ESKAPEEcs导致BSI的患病率和易感性。方法：从血培养标本中分离出2591株独特的ESKAPEEc病原菌，其中1.281株（49.4%）呈阳性。2016年至2019年，ESKAPEEc发病率有所上升，在新冠肺炎大流行期间有所下降。结果：最常见的病原菌为肺炎克雷伯菌（34.3%），对碳青霉烯耐药的肺炎克雷伯菌（CR）为61.8%，鲍曼不动杆菌（A.baumannii）为90.4%，耐甲氧西林金黄色葡萄球菌（MRSA）和耐万古霉素粪大肠杆菌（VRE）的检出率分别为38.6%和29.4%。结论：我们的研究结果显示，在BSI中，ESKAPEEc和AMR的发生率很高。卫生保健环境和社区中的抗生素政策和限制将在未来的解决方案中发挥重要作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Jundishapur Journal of Microbiology MICROBIOLOGY-

CiteScore

1.30

自引率

0.00%

发文量

审稿时长

6-12 weeks

期刊介绍： Jundishapur Journal of Microbiology, (JJM) is the official scientific Monthly publication of Ahvaz Jundishapur University of Medical Sciences. JJM is dedicated to the publication of manuscripts on topics concerning all aspects of microbiology. The topics include medical, veterinary and environmental microbiology, molecular investigations and infectious diseases. Aspects of immunology and epidemiology of infectious diseases are also considered.