Effect of acupuncture at three different acupoints on electrical activity of gastric distention-affected neurons in rat medial vestibular nucleus

IF 2 4区 医学 Q2 INTEGRATIVE & COMPLEMENTARY MEDICINE
Liang Chao , Wang Yuan , Xu Bin , Yu Zhi
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引用次数: 4

Abstract

OBJECTIVE

To observe the effect of gastric distention (GD) and acupuncture at three different acupoints on the spontaneous discharge of neurons in the medial vestibular nucleus (MVN), and to clarify the specific function of the MVN in the central integration mechanism underlying acupuncture regulation.

METHODS

GD was conducted using a balloon inserted in the stomach cavity, and acupuncture was performed separately at each of three acupoints: Zusanli (ST 36), Quchi (LI 11), and Weishu (BL 21). The effect of acupuncture and GD on the spontaneous discharge of MVN neurons was assessed using a glass microelectrode filled with a sodium acetate electrolyte solution containing 1% pontamine sky blue; the discharge signals from the neurons were amplified by the microelectrode amplifier and recorded in the Spike2 system.

RESULTS

GD and acupuncture significantly affected the spontaneous discharge of MVN neurons. Furthermore, acupuncture at Zusanli (ST 36) and Weishu (BL 21) was significantly more effective at altering the discharge of GD-responsive MVN neurons compared with GD-nonresponsive neurons.

CONCLUSION

GD and acupuncture at three different acupoints affected the electrical activity of MVN neurons. The MVN is involved in the central integration mechanism underlying acupuncture regulation of gastric functions. The effects of acupuncture on gastric function may therefore be mediated via these particular MVN neurons.

针刺三个不同穴位对大鼠前庭内侧核胃扩张神经元电活动的影响
目的观察胃胀(GD)和针刺三个不同穴位对前庭内侧核(MVN)神经元自发放电的影响,阐明MVN在针刺调节中枢整合机制中的具体功能。方法采用胃球囊穿刺法,分别针刺足三里(ST 36)、曲池(LI 11)、胃枢(BL 21) 3个穴位。针刺和GD对MVN神经元自发放电的影响采用含有1% pontamine天蓝的醋酸钠电解质溶液填充的玻璃微电极;神经元放电信号经微电极放大器放大后记录在Spike2系统中。结果gd和针刺对MVN神经元自发放电有显著影响。此外,针刺足三里(ST 36)和胃枢(BL 21)在改变gd反应神经元的MVN放电方面明显比gd不反应神经元更有效。结论d和针刺三个不同穴位对MVN神经元的电活动有影响。MVN参与了针刺调节胃功能的中枢整合机制。因此,针刺对胃功能的影响可能是通过这些特殊的MVN神经元介导的。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Journal of Traditional Chinese Medicine
Journal of Traditional Chinese Medicine INTEGRATIVE & COMPLEMENTARY MEDICINE-
CiteScore
2.40
自引率
3.80%
发文量
32269
审稿时长
2 months
期刊介绍: Journal of Traditional Chinese Medicine(JTCM) is devoted to clinical and theortical research on the use of acupuncture and Oriental medicine. The main columns include Clinical Observations, Basic Investigations, Reviews, Questions and Answers, an Expert''s Forum, and Discussions of Clinical Cases. Its key topics include acupuncture and electro-acupuncture, herbal medicine, homeopathy, masseotherapy, mind-body therapies, palliative care, and other CAM therapies.
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