Promising biocemical markers of Parkinson's disease

IF 0.2 Q4 MEDICINE, GENERAL & INTERNAL

Bulletin of Russian State Medical University Pub Date : 2023-08-01 DOI:10.24075/brsmu.2023.030

OA Gusyakova, SV Smirnov, OYu Kuznetsova, AR Apergenova, AR Albikova

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Abstract

Parkinson's disease (PD) is a chronic neurodegenerative disease associated with specific neurological deficits in patients, it mainly affects dopaminergic neurons in the substantia nigra causing accumulation of the neurotoxic amounts of aggregated α-synuclein protein in the neuronal cell bodies. The paper reports the authors' view of certain pathochemical and biochemical aspects of the Parkinson’s disease development in terms of interplay between the metabolic pathways of catecholamines and pigments, particularly the possible pathway of neuromelanin synthesis in the neuronal cell bodies and its importance in the life of cells. Assessment of the use of certain neurodegenerative disorder biomarkers, which are of direct pathognomonic value, in the laboratory diagnosis of the disease is provided. It is suggested to use the results in the field of deeper understanding of biochemical patterns underlying neuronal death for early diagnosis of PD in individuals of different age groups, as well as for further study of pathogenesis based on fundamental biochemistry and pathobiochemistry of intracellular processes.

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帕金森病有前景的生物化学标记物

帕金森病(PD)是一种慢性神经退行性疾病，伴患者特异性神经功能缺损，主要影响黑质多巴胺能神经元，导致神经元细胞体内聚集的α-突触核蛋白的神经毒性量积累。本文从儿茶酚胺和色素代谢途径的相互作用，特别是神经黑色素在神经元细胞体中合成的可能途径及其在细胞生命中的重要性等方面阐述了作者对帕金森病发展的某些病理化学和生化方面的看法。评估使用某些神经退行性疾病的生物标志物，这是直接的病理价值，在疾病的实验室诊断提供。建议将这一结果应用于更深入了解神经元死亡的生化模式，用于不同年龄组个体PD的早期诊断，以及基于细胞内过程的基础生物化学和病理生物化学进一步研究发病机制。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Bulletin of Russian State Medical University MEDICINE, GENERAL & INTERNAL-

CiteScore

0.80

自引率

0.00%

发文量

期刊介绍： Bulletin of Russian State Medical University (Bulletin of RSMU, ISSN Print 2500–1094, ISSN Online 2542–1204) is a peer-reviewed medical journal of Pirogov Russian National Research Medical University (Moscow, Russia). The original language of the journal is Russian (Vestnik Rossiyskogo Gosudarstvennogo Meditsinskogo Universiteta, Vestnik RGMU, ISSN Print 2070–7320, ISSN Online 2070–7339). Founded in 1994, it is issued once every two months publishing articles on clinical medicine and medical and biological sciences, first of all oncology, neurobiology, allergy and immunology, medical genetics, medical microbiology and infectious diseases. Every issue is thematic. Deadlines for manuscript submission are announced in advance. The number of publications on topics in spite of the issue topic is limited. The journal accepts only original articles submitted by their authors, including articles that present methods and techniques, clinical cases and opinions. Authors must guarantee that their work has not been previously published elsewhere in whole or in part and in other languages and is not under consideration by another scientific journal. The journal publishes only one review per issue; the review is ordered by the editors.