Prediction of the effect of the photodynamic therapy on survival in patients with stage IV of pancreatic cancer

Q3 Medicine

Biomedical Photonics Pub Date : 2023-01-31 DOI:10.24931/2413-9432-2022-11-4-25-31

A. Tseimakh, S. Shtofin, V. Kurtukov, V. Teplukhin, Ia. N. Shoykhet, M. Tseimakh

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Abstract

The article presents the results of a study of survival after complex palliative treatment of patients with malignant tumors of the pancreas stage IV in two comparable groups of patients. The aim of the study is to determine the prognostic factors affecting survival in patients with stage IV pancreatic cancer who received local and systemic photodynamic therapy. In the main group, which consisted of 19 patients with histologically veried stage IV pancreatic maligant tumor, palliative treatment was performed using photodynamic therapy. In the comparison group, consisting of 28 patients with histologically veried malignant tumor of the pancreas stage IV, palliative treatment was performed without the use of photodynamic therapy. On the background of the use of local and systemic photodynamic therapy in the main group it was observed a statistically significant increase in life expectancy compared with the comparison group. The three-month survival of patients who received local and systemic photodynamic therapy is affected by the level of brinogen before treatment. The level of brinogen above 3.4 g/l makes it possible to predict a decrease in the probability of three-month survival after photodynamic therapy. Thus, complex treatment with the use of photodynamic therapy for stage IV malignant tumors of the pancreas can increase the survival rate of patients.

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光动力治疗对IV期胰腺癌患者生存影响的预测

本文介绍了两组可比较的胰腺恶性肿瘤IV期患者复杂姑息治疗后生存率的研究结果。该研究的目的是确定影响接受局部和全身光动力治疗的IV期胰腺癌患者生存的预后因素。主组19例经组织学证实的IV期胰腺恶性肿瘤患者，采用光动力治疗进行姑息性治疗。对照组为28例经组织学证实的胰腺恶性肿瘤IV期患者，采用姑息治疗，不采用光动力治疗。在主要组使用局部和全身光动力疗法的背景下，与对照组相比，观察到预期寿命有统计学意义上的显着增加。接受局部和全身光动力治疗的患者的三个月生存率受治疗前brinogen水平的影响。高于3.4 g/l的brinogen水平可以预测光动力治疗后三个月生存率的降低。因此，结合光动力疗法对胰腺IV期恶性肿瘤进行综合治疗可提高患者的生存率。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Biomedical Photonics Medicine-Surgery

CiteScore

1.80

自引率

0.00%

发文量

审稿时长

8 weeks

期刊介绍： The main goal of the journal – to promote the development of Russian biomedical photonics and implementation of its advances into medical practice. The primary objectives: - Presentation of up-to-date results of scientific and in research and scientific and practical (clinical and experimental) activity in the field of biomedical photonics. - Development of united Russian media for integration of knowledge and experience of scientists and practitioners in this field. - Distribution of best practices in laser medicine to regions. - Keeping the clinicians informed about new methods and devices for laser medicine - Approval of investigations of Ph.D candidates and applicants.