Sono and nano: A perfect synergy for eco-compatible Biginelli reaction

IF 1.3 3区化学 Q3 CHEMISTRY, ORGANIC

Heterocyclic Communications Pub Date : 2022-01-01 DOI:10.1515/hc-2022-0003

Marzieh Tahmasbi, Nadiya Koukabi, Ozra Armandpour

引用次数: 4

Abstract

Abstract In this study, we evaluated the performance of nano-γ-Fe2O3–SO3H catalyst in the Biginelli reaction and synthesized 3,4-dihydropyrimidine-2-(1H)-ones. This reaction was carried out under solvent-free and ultrasonic irradiation conditions and belonged to one-pot multicomponent reactions (MCRs) with an adopted aromatic aldehyde, ethyl acetoacetate, and urea as starting materials for the beginning of the reaction. The synthesized materials were efficient in synthesizing 3,4-dihydropyrimidine-2-(1H)-ones via the Biginelli reaction under reaction conditions. Thus, the advantages of using nano-γ-Fe2O3–SO3H in the Biginelli reaction are short reaction time, high efficiency, green method, solvent free, and cost-effective. Furthermore, nano-γ-Fe2O3–SO3H as a heterogeneous catalyst can be recycled five times without significantly reducing catalytic activity. Graphical abstract

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声纳和纳米:生态兼容的比基内利反应的完美协同作用

摘要在本研究中，我们评估了纳米-γ-Fe2O3–SO3H催化剂在Biginelli反应中的性能，并合成了3，4-二氢嘧啶-2-（1H）-酮。该反应在无溶剂和超声波照射条件下进行，属于一锅多组分反应（MCRs），采用芳香醛、乙酰乙酸乙酯和尿素作为反应起始原料。所合成的材料在反应条件下通过Biginelli反应有效地合成了3，4-二氢嘧啶-2-（1H）-酮。因此，在Biginelli反应中使用纳米-γ-Fe2O3–SO3H的优点是反应时间短、效率高、绿色方法、无溶剂和成本效益高。此外，纳米-γ-Fe2O3–SO3H作为非均相催化剂可以循环使用五次，而不会显著降低催化活性。图形摘要

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来源期刊

Heterocyclic Communications 化学-有机化学

CiteScore

3.80

自引率

4.30%

发文量

审稿时长

1.4 months

期刊介绍： Heterocyclic Communications (HC) is a bimonthly, peer-reviewed journal publishing preliminary communications, research articles, and reviews on significant developments in all phases of heterocyclic chemistry, including general synthesis, natural products, computational analysis, considerable biological activity and inorganic ring systems. Clear presentation of experimental and computational data is strongly emphasized. Heterocyclic chemistry is a rapidly growing field. By some estimates original research papers in heterocyclic chemistry have increased to more than 60% of the current organic chemistry literature published. This explosive growth is even greater when considering heterocyclic research published in materials science, physical, biophysical, analytical, bioorganic, pharmaceutical, medicinal and natural products journals. There is a need, therefore, for a journal dedicated explicitly to heterocyclic chemistry and the properties of heterocyclic compounds.