{"title":"Microwave Induced One Pot Ugi Multicomponent Reaction of Fluoroquino Lone Scaffolds: Their Biological Evaluation","authors":"N. Patel, R. Parmar, Hetal I. Soni","doi":"10.2174/2213346107999201224110618","DOIUrl":null,"url":null,"abstract":"\n\nMicrowave irradiated facile and efficient process for one pot Ugi multicomponent reaction\nof a novel series of fluoroquinolone scaffolds is described here. On the basis of this approach,\na new route to synthesize this privileged scaffolds was designed with higher yields, a\nclean procedure, time efficient and simple work-up. Our aim is to develop a biologically active\nfluoroquinolone scaffolds by microwave induced one pot Ugi multicomponent reaction. All the\nsynthesized molecules were characterized by IR, 1H NMR, 13C NMR, and Mass spectra. The antimicrobial\nactivity of the synthesized compounds was screened against two Gram-negative bacteria\n(Escherichia coli, Pseudomonas aeruginosa), two Gram-positive bacteria (Staphylococcus\naureus, Streptococcus pyogenes), and three fungi (Candida albicans, Aspergillus niger, Aspergillus\nclavatus) utilizing the MIC (Minimal Inhibitory Concentration) method and antitubercular activity\nH37Rv utilizing L. J. Slope method. Some of these novel derivatives demonstrate moderate\nto good in vitro antibacterial, antifungal and antitubercular activities.\n","PeriodicalId":10856,"journal":{"name":"Current Green Chemistry","volume":null,"pages":null},"PeriodicalIF":1.1000,"publicationDate":"2020-12-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Current Green Chemistry","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.2174/2213346107999201224110618","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"CHEMISTRY, MULTIDISCIPLINARY","Score":null,"Total":0}
引用次数: 0
Abstract
Microwave irradiated facile and efficient process for one pot Ugi multicomponent reaction
of a novel series of fluoroquinolone scaffolds is described here. On the basis of this approach,
a new route to synthesize this privileged scaffolds was designed with higher yields, a
clean procedure, time efficient and simple work-up. Our aim is to develop a biologically active
fluoroquinolone scaffolds by microwave induced one pot Ugi multicomponent reaction. All the
synthesized molecules were characterized by IR, 1H NMR, 13C NMR, and Mass spectra. The antimicrobial
activity of the synthesized compounds was screened against two Gram-negative bacteria
(Escherichia coli, Pseudomonas aeruginosa), two Gram-positive bacteria (Staphylococcus
aureus, Streptococcus pyogenes), and three fungi (Candida albicans, Aspergillus niger, Aspergillus
clavatus) utilizing the MIC (Minimal Inhibitory Concentration) method and antitubercular activity
H37Rv utilizing L. J. Slope method. Some of these novel derivatives demonstrate moderate
to good in vitro antibacterial, antifungal and antitubercular activities.